Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …

Background Unilateral renal agenesis (URA) is associated with other congenital anomalies
of the kidney and urinary tract (CAKUT) and extra-renal anomalies. However, the reported …

Background. Many papers are published on cohorts with unilateral multicystic dysplastic kidney
(MCDK) patients, but show variable results as to the incidence of associated urinary tract …

Background. Children with a solitary functioning kidney (SFK) have an increased risk of
developing hypertension, albuminuria and chronic kidney disease in later life. This renal injury is …

The implementation of whole-exome sequencing in clinical diagnostics has generated a
need for functional evaluation of genetic variants. In the field of inborn errors of metabolism (IEM…

OBJECTIVE: The hyperfiltration hypothesis implies that children with a solitary functioning
kidney are at risk to develop hypertension, proteinuria, and chronic kidney disease. We sought …

Renal tract malformations are congenital anomalies of the kidneys and/or lower urinary tract.
One challenging feature of these conditions is that they can present not only prenatally but …

Background and Objectives During the newborn period and early infancy, renal function
matures, resulting in changes in the glomerular filtration rate (GFR). This study was performed to …

Aim: According to the hyperfiltration hypothesis, a low nephron endowment will lead to
hyperfiltration in the remaining glomeruli and is associated with systemic hypertension, …

Congenital anomalies of the kidney and urinary tract are the major cause of ESRD in
childhood. Children with a solitary functioning kidney form an important subgroup of congenital …