Human carboxylesterase (CES) 1A is responsible for the biotransformation of angiotensin-converting
enzyme (ACE) inhibitors such as imidapril and temocapril. Because antidiabetic or …

The mammalian neocortex contains many cell types, but whether they organize into repeated
structures has been unclear. We discovered that major cell types in neocortical layer 5 …

Phenacetin was withdrawn from the market because it caused renal failure in some patients.
Many reports indicated that the nephrotoxicity of phenacetin is associated with the …

Variational Autoencoder (VAE)-based generative models offer flexible representation learning
by incorporating meta-priors, general premises considered beneficial for downstream …

10.7554/eLife.10907.001 Many cell-intrinsic mechanisms have been shown to regulate
neuronal subtype specification in the mammalian neocortex. However, how much cell …

Cytochrome P450 3A4 is the predominant isoform in liver, and it metabolizes more than 50%
of the clinical drugs commonly used. However, CYP3A4 is also responsible for metabolic …

Kampo is a traditional Japanese herbal medicine and widely used in clinical practice in Japan.
Little is known about interactions between Kampo and other medicines. Kampo contains …

An inter-regional cortical tract is one of the most fundamental architectural motifs that
integrates neural circuits to orchestrate and generate complex functions of the human brain. To …

: Kampo medicine is traditional Japanese medicine modified from the Chinese original. Kampo
medicine is a mixture of several medicinal herbs and includes many ingredients such as …

Gap junctions mediate electrical coupling between neurons and modulate their firing activity.
In mouse neocortical layer 5, the major types of pyramidal neurons organize into cell type-…