(1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-d-glucitol (TS-071) is a Potent, Selective Sodium-Dependent Glucose Cotransporter 2 …

…, Y Fukasawa, I Iida, N Hagima… - Journal of medicinal …, 2010 - ACS Publications
Derivatives of a novel scaffold, C-phenyl 1-thio-d-glucitol, were prepared and evaluated for
sodium-dependent glucose cotransporter (SGLT) 2 and SGLT1 inhibition activities. …

Involvement of organic cation transporters in the clearance and milk secretion of thiamine in mice

…, N Ito, X Zhang, K Hachiuma, N Hagima… - Pharmaceutical …, 2015 - Springer
Purpose To investigate the role of organic cation transporters (Octs) and multidrug and toxin
extrusion protein 1 (Mate1) in the disposition of thiamine. Methods The uptake of [ 3 H]…

Deuterium-Resistant Algal Cell Line for D Labeling of Heterotrophs Expresses Enhanced Level of Hsp60 in D2O Medium

K Unno, N Hagima, T Kishido, S Okada… - Applied and …, 2005 - Am Soc Microbiol
Fully deuterated components from autotrophic cell lysate are useful materials for labeling of
heterotrophs with deuterium. To facilitate the faster production of deuterated algal lysate, we …

Differences in Cytochrome P450 Forms Involved in the Metabolism ofN, N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl] ethylamine monohydrochloride (NE-100) …

T Yamamoto, N Hagima, M Nakamura, Y Kohno… - Drug metabolism and …, 2003 - ASPET
N,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100)
has been developed to treat subjects with schizophrenia. This drug is mainly excreted in …

Growth Delay and Intracellular Changes in Chlorella ellipsoidea C-27 as a Result of Deuteration

K Unno, I Ando, N Hagima, S Yokogaki… - Plant and cell …, 1992 - academic.oup.com
The effects of deuterium (D) on Chlorella ellipsoidea C-27 were investigated. Cells grown in
a medium prepared with deuterium oxide (D 2 O) showed pronounced delays in cell growth …

Metabolism of N, N-dipropyl-2-[4-methoxy-3-(2-phenyl-ethoxy)-phenyl]-ethyl-amine-monohydrochloride (NE-100), a novel sigma ligand: contribution of cytochrome …

T Yamamoto, N Hagima, M Fukasawa… - Drug metabolism and …, 2003 - Elsevier
In the present study, human cytochrome P450 (CYP) forms involved in producing the
primary metabolites of NE-100 were identified. Major metabolites of NE-100 in human liver …

[PDF][PDF] Bibliographic information published by the Deutsche Nationalbibliothek

W Börner, C Kral-Börner, MSW Hämmerlegasse… - researchgate.net
Early watercraft (EW) can be considered as one of the earliest and most significant human
inventions from technical, cultural, and environmental perspectives. The discovery that water—…

Maastricht, the city, the maquette and the collection at the Palais de Beaux-Arts in Lille (France), Photogrammetry and digital twin creation for an ancient urban …

G Verdiani, S Gilbert - … : Digital archaeology of large urban and …, 2021 - flore.unifi.it
During the CHNT 2017, while attending together one of the social events, Gilber discussed
with Willem Beex the possibility of scanning the famous maquette of Maastricht from 1750. …

[HTML][HTML] Global assessment of the effectiveness of adaptation in coastal areas based on RCP/SSP scenarios

M Tamura, N Kumano, M Yotsukuri, H Yokoki - Climatic Change, 2019 - Springer
The objective of this study is to assess the global impact of sea level rise and to evaluate the
effectiveness of adaptation. Global areas of inundation due to sea level rise are identified. …

[PDF][PDF] Coherent Synchrotron Radiation and Microwave Instability in Electron Storage Rings

D Zhou - 2011 - inspirehep.net
This thesis work was dedicated to investigating coherent synchrotron radiation (CSR) and
microwave instability (MWI) in electron rings. CSR is an important issue in modern electron/…