In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active …
…, DS Compton, RL Mcleod, NP Yumibe… - … of Pharmacology and …, 1997 - ASPET
SCH48461 is a selective and highly potent inhibitor of cholesterol absorption. In rats,
SCH48461 is rapidly and completely metabolized in the first pass through the body. To compare …
SCH48461 is rapidly and completely metabolized in the first pass through the body. To compare …
The discovery, preclinical, and early clinical development of potent and selective GPR40 agonists for the treatment of type 2 diabetes mellitus (LY2881835 …
…, JT Johnson, NP Yumibe, Q Chen, P Maiti… - 2016 - ACS Publications
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1)
is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, …
is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, …
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor α agonist
…, RW Zink, NP Yumibe… - Journal of medicinal …, 2003 - ACS Publications
… Yumibe … Yumibe - Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly
Corporate Center, Indianapolis, Indiana 46285, and Ligand Pharmaceuticals, 10275 …
Corporate Center, Indianapolis, Indiana 46285, and Ligand Pharmaceuticals, 10275 …
Fabp3 as a biomarker of skeletal muscle toxicity in the rat: comparison with conventional biomarkers
…, KM Credille, DD Brown, NP Yumibe… - Toxicological …, 2008 - academic.oup.com
Fatty acid binding protein 3 (Fabp3) has been used as a serological biomarker of cardiac
injury, but its utility as a preclinical biomarker of injury to skeletal muscle is not well described. …
injury, but its utility as a preclinical biomarker of injury to skeletal muscle is not well described. …
The Use of in Vitro Metabolic Stability for Rapid Selection of Compounds in Early Discovery Based on Their Expected Hepatic Extraction Ratios
YY Lau, G Krishna, NP Yumibe, DE Grotz… - Pharmaceutical …, 2002 - Springer
Purpose. The in vivo hepatic extraction ratio of cynomolgus monkeys was correlated with
the corresponding in vitro extraction ratios that were determined in monkey microsomal …
the corresponding in vitro extraction ratios that were determined in monkey microsomal …
Difference in the pharmacokinetics and hepatic metabolism of antidiabetic drugs in zucker diabetic fatty and sprague-dawley rats
…, RD Moulton, KC Cassidy, NP Yumibe… - Drug Metabolism and …, 2016 - ASPET
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early
onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic …
onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic …
Discovery of LY3104607: a potent and selective G protein-coupled receptor 40 (GPR40) agonist with optimized pharmacokinetic properties to support once daily oral …
…, LA Adams, O Cabrera, X Ma, NP Yumibe… - Journal of Medicinal …, 2018 - ACS Publications
As a part of our program to identify potent GPR40 agonists capable of being dosed orally
once daily in humans, we incorporated fused heterocycles into our recently disclosed …
once daily in humans, we incorporated fused heterocycles into our recently disclosed …
Syn and anti bent hydrazine radical cations. Effect of. sigma.,. pi. mixing on spectral properties
SF Nelsen, SC Blackstock, NP Yumibe… - Journal of the …, 1985 - ACS Publications
Nitrogen ESR splitting constants, a (N), and,* optical absorption spectrum maxima, Xm, are
compared for 15 examples of R4N2+. Molecular orbital calculations of these quantities are …
compared for 15 examples of R4N2+. Molecular orbital calculations of these quantities are …
Mechanistic aspects of cytochrome P450-hydroperoxide interactions: substituent effects on degradative pathways
JA Thompson, NP Yumibe - Drug Metabolism Reviews, 1989 - Taylor & Francis
In the early 1970s it was discovered that hydroperoxides can support the cytochrome P-450-catalyzed
oxidation of a wide variety of compounds in the absence of NADPH [l-31. The …
oxidation of a wide variety of compounds in the absence of NADPH [l-31. The …
Conformations of hexahydropyridazine cation radicals
SF Nelsen, NP Yumibe - The Journal of Organic Chemistry, 1985 - ACS Publications
The variable temperature ESR spectra of the cations of 1, 2-dimethylhexahydropyridazine (3)
cis-and trons-1, 2, 3, 6-tetramethylhexahydropyridazine (4 and 5), trans-3, 4-dimethyl-3, 4-…
cis-and trons-1, 2, 3, 6-tetramethylhexahydropyridazine (4 and 5), trans-3, 4-dimethyl-3, 4-…