Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species

SL Michael, NR Pumford, PR Mayeux… - …, 1999 - Wiley Online Library
Hepatotoxic doses of acetaminophen to mice produce not only acetaminophen‐protein
adducts in the centrilobular cells of the liver, but nitrotyrosine‐protein adducts in the same cells, …

Selective protein covalent binding and target organ toxicity

SD Cohen, NR Pumford, EA Khairallah… - Toxicology and applied …, 1997 - Elsevier
Protein covalent binding by xenobiotic metabolites has long been associated with target
organ toxicity but mechanistic involvement of such binding has not been widely demonstrated. …

Nitrotyrosine− protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice

JA Hinson, SL Pike, NR Pumford… - Chemical research in …, 1998 - ACS Publications
Treatment of mice with a toxic dose of acetaminophen (300 mg/kg, ip) significantly increased
hepatotoxicity at 4 h, as evidenced by histological necrosis in the centrilobular areas of the …

Mitochondrial oxidative damage in chicken skeletal muscle induced by acute heat stress

A Mujahid, NR Pumford, W Bottje… - The Journal of Poultry …, 2007 - jstage.jst.go.jp
Mitochondria have long been known to play a critical role in maintaining bioenergetic status
under physiological conditions. Our previous studies have shown that acute heat stress …

Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress

JD Gibson, NR Pumford, VM Samokyszyn… - Chemical research in …, 1996 - ACS Publications
The hepatotoxicity of acetaminophen is believed to be mediated by the reactive metabolite N-acetyl-p-benzoquinone
imine; however, the mechanism by which this metabolite produces …

Identification and characterization of lactic acid bacteria in a commercial probiotic culture

…, JD Latorre, MJ Morgan, NR Pumford… - … of Microbiota, Food …, 2014 - jstage.jst.go.jp
The use of probiotics in agriculture has increased as potential alternatives to antibiotics used
as growth promoters, and in select cases, for control of specific enteric pathogens [1, 2]. For …

[PDF][PDF] Immunochemical quantitation of 3-(cystein-S-yl) acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice.

NR Pumford, JA Hinson, DW Potter… - … of Pharmacology and …, 1989 - Citeseer
ABBREVIATiONS: APAP, acetaminophen, N-acetyl-p-aminophenol; NAPOI, N-acetyl-p-benzoquinone
imine; AB ELISA, avidin biotin-amplified enzyme-linked immunosorbent assay; …

Immunochemical detection of oxidized proteins

…, NC Halmes, JA Hinson, NR Pumford - Chemical research in …, 1993 - ACS Publications
An immunochemical assay was developed to detect carbonyl moieties that result from
oxidative damage to proteins. Bovine serum albumin was reacted with hydroxyl radicals …

[PDF][PDF] A sensitive immunochemical assay for acetaminophen-protein adducts.

DW Roberts, NR Pumford, DW Potter… - … of Pharmacology and …, 1987 - Citeseer
Materials and Methods Reagents.[3H-ring] Acetaminophen(1.15 Ci/mmol) was provided by
Dr. Robert W. Roth (Midwest Research Institute, Kansas City, MO). Amphogel was a product …

Immunoblot analysis of protein containing 3-(cystein-S-yl) acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice

NR Pumford, JA Hinson, RW Benson… - Toxicology and applied …, 1990 - Elsevier
The hepatotoxicity of acetaminophen is believed to be mediated by the metabolic activation
of acetaminophen to N-acetyl-p-benzoquinone imine which covalently binds to cysteinyl …