Design and synthesis of conformationally constrained glucagon analogues

…, Y Lin, JM Ahn, M Siegel, NN Mollova… - Journal of medicinal …, 2000 - ACS Publications
Glucagon was systematically modified by forming lactam bridges within the central region of
the molecule to give conformationally constrained cyclic analogues. Six cyclic glucagon …

Fast atom bombardment mass spectrometry of phospholipids in human cerebrospinal fluid

NN Mollova, IM Moore, J Hutter… - Journal of Mass …, 1995 - Wiley Online Library
Lipid extracts of cerebrospinal fluid (CSF) collected from children with leukemia were separated
on normal‐phase high‐performance liquid chromatography (HPLC) and analyzed by …

Chemical ionization mass spectrometry of valepotriates using isobutane as reactant gas

NV Handjieva, NN Mollova, SS Popov - Planta medica, 1987 - thieme-connect.com
A series of known valepotriates isolated from some Valeriana species and their
transformation products have been studied by CIMS (isobutane). The compounds have been …

Chemical ionization mass spectrometry of some monoterpene gentianine alkaloids and their derivatives

VA Popov, NN Mollova, SM Veleva… - Biological mass …, 1992 - Wiley Online Library
The chemical ionization mass spectra of eight monoterpene alkaloids from the gentianine
group and their derivatives were investigated. Isobutane, methanol, ammonia, methylamine, …

In vitro interactions between a potential muscle relaxant E2101 and human cytochromes P450

ZY Zhang, BM King, NN Mollova, YN Wong - Drug metabolism and …, 2002 - ASPET
E2101 orN-methyl-[1-[1-(2-fluorophenethyl)piperidine-4-yl]-1H-indol-6-yl] acetamide, an
antagonist of 5-hydroxytryptamine receptor subtypes 1A and 2, is currently under development …

Chemical ionization mass spectrometry with amines as reactant gases. VIII—amine chemical ionization mass spectrometry of some steroids

TS Milkova, NN Mollova… - Biological mass …, 1991 - Wiley Online Library
The chemical ionization mass spectra of different groups of steroids (sterols, dihydroxy
sterols, epoxy sterols and epidioxy sterols) were investigated. Triethylamine, diethylamine, …

Characterization of linear and cyclic glucagon analogs by fast atom bombardment mass spectrometry

NN Mollova, KH Schram, Y Lin… - Biological mass …, 1993 - Wiley Online Library
Fast atom bombardment mass spectral mapping of endoproteinase Asp‐N digest mixtures
is used for characterization of new synthetic linear and cyclic glucagon analogs. The results …

[CITATION][C] Mass spectrometric investigation of some [1]benzopyrano[3,4‐c]pyrazole and [1]benzopyrano[4,3‐d]isoxazole derivatives

IN Kostova, NN Mollova - Organic mass spectrometry, 1988 - Wiley Online Library
The fragmentation behaviour of some [1] benzopyrano [3, 4‐c] pyrazole and [1] benzopyrano
[4, 3‐d] isoxazole derivatives under electron impact is described.

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to …

…, S Rajamani, B Stafford, J Tang, N Mollova… - Bioorganic & Medicinal …, 2016 - Elsevier
We started with a medium throughput screen of heterocyclic compounds without basic amine
groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as …

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and …

…, CH Li, AK Dhalla, S Rajamani, N Mollova… - Journal of medicinal …, 2016 - ACS Publications
Late sodium current (late I Na ) is enhanced during ischemia by reactive oxygen species (ROS)
modifying the Na v 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-…