User profiles for Neville J. Butcher

Neville J Butcher

University of Queensland
Verified email at uq.edu.au
Cited by 1965

Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials

GM Mortimer, NJ Butcher, AW Musumeci, ZJ Deng… - ACS …, 2014 - ACS Publications
While plasma proteins can influence the physicochemical properties of nanoparticles, the
adsorption of protein to the surface of nanomaterials can also alter the structure and function of …

Unravelling the stealth effect

NJ Butcher, GM Mortimer, RF Minchin - Nature nanotechnology, 2016 - nature.com
Poly (ethylene glycol) helps nanomaterials evade the immune system by modifying the
composition of proteins that are adsorbed on the surface of the materials.

Hypoxia-mediated drug resistance in breast cancers

CE McAleese, C Choudhury, NJ Butcher, RF Minchin - Cancer letters, 2021 - Elsevier
Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances, …

Arylamine N-acetyltransferase 1: a novel drug target in cancer development

NJ Butcher, RF Minchin - Pharmacological reviews, 2012 - ASPET
The human arylamine N-acetyltransferases first attracted attention because of their role in
drug metabolism. However, much of the current literature has focused on their role in the …

Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells

JM Tiang, NJ Butcher, RF Minchin - Biochemical and biophysical research …, 2010 - Elsevier
Arylamine N-acetyltransferase 1 is a phase II metabolizing enzyme that has been associated
with certain breast cancer subtypes. While it has been linked to breast cancer risk because …

[HTML][HTML] RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition

JM Tiang, NJ Butcher, C Cullinane, PO Humbert… - PloS one, 2011 - journals.plos.org
Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation
of arylamine and hydrazine substrates. It also has a role in the catabolism of the folate …

[HTML][HTML] Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and …

NJ Butcher, A Arulpragasam, RF Minchin - Journal of Biological Chemistry, 2004 - ASBMB
Many drugs and chemicals found in the environment are either detoxified by N-acetyltransferase
1 (NAT1, EC 2.3.1.5) and eliminated from the body or bioactivated to metabolites that …

Arylamine n-acetyltransferase i

…, CR Wagner, F Rodrigues-Lima, NJ Butcher - The international journal …, 2007 - Elsevier
Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of
arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and …

Effects of human arylamine N‐acetyltransferase I knockdown in triple‐negative breast cancer cell lines

JM Tiang, NJ Butcher, RF Minchin - Cancer medicine, 2015 - Wiley Online Library
Expression of human arylamine N‐acetyltransferase I ( NAT 1) has been associated with
various cancer subtypes and inhibition of this enzyme with small molecule inhibitors or si RNA …

Substrate-dependent regulation of human arylaminen-acetyltransferase-1 in cultured cells

NJ Butcher, KF Ilett, RF Minchin - Molecular pharmacology, 2000 - ASPET
Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely
distributed throughout the body. In the present study, we provide evidence for substrate-…