Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in
several neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease and …

Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory
and anti-proliferative properties potentially beneficial in cancers, in particular in the …

Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid
component and altered cholesterol metabolism are closely linked, but the relationship …

Although the natural flavonoid fisetin (3,3′,4′,7-tetrahydroxyflavone) has been recently
identified as an anticancer agent with antiangiogenic properties in mice, its in vivo …

Despite extensive research, the pathogenesis of neonatal necrotizing enterocolitis (NEC)
remains elusive. The aim of our work was to investigate the role of bacterial strains involved in …

Background: Phthalates are environmental contaminants commonly used as plasticizers in
polyvinyl chloride (PVC) products. Recently, exposure to phthalates has been associated …

The Aryl hydrocarbon Receptor(AhR) is among the most important receptors which bind
pollutants; however it also regulates signaling pathways independently of such exposure. We …

The senile plaque is a hallmark lesion of Alzheimer disease (AD). We compared, without a
priori, the lipidome of the senile plaques and of the adjacent plaque-free neuropil. The …

Age-related macular degeneration (AMD) is the most common cause of severe vision loss
worldwide. Amyloid β involvement in degenerative diseases such as AMD is well known and …

Metabolomics in clinical toxicology aim at reliably identifying and semi-quantifying a broad
array of endogenous and exogenous metabolites using dedicated analytical methods. Here, …