Helminths are multicellular parasitic worms that comprise a major class of human pathogens
and cause an immense amount of suffering worldwide. Helminths possess an abundance …

Schistosoma mansoni and other Schistosoma sp. are multicellular parasitic helminths (worms)
that infect humans and mammals worldwide. Infection by these parasites, which results in …

Inflammation and infection downregulate the activity and expression of cytochrome P450s (P450s)
and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. …

The mammalian immune system responds to eukaryotic glycan antigens during infections,
cancer, and autoimmune disorders, but the immunological bases for such responses are …

Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by
chemotherapy and for which no vaccine exists. While partial resistance in people may develop …

… A major glycan antigen targeted by IgG from different infected species is the FLDNF
epitope [Fucα3GalNAcβ4(Fucα3)GlcNAc-R], which is also recognized by the IgG monoclonal …

Schistosomiasis caused by infection with parasitic helminths of Schistosoma spp. is a major
global health problem due to inadequate treatment and lack of a vaccine. The immune …

Maternal sepsis is a leading cause of morbidity and mortality during pregnancy. Escherichia
coli is a primary cause of bacteremia in women and occurs more frequently during …

Schistosomiasis is a debilitating parasitic disease of humans, endemic in tropical areas, for
which no vaccine is available. Evidence points to glycan antigens as being important in …

… ’t let me lose hope or my sense of self-worth: My parents, my MD/PhD classmates (especially
Howard Chiou) and program director Mary Horton, and my husband Adam Prasanphanich. …