CYP3A4, the major form of cytochrome P450 (P450) expressed in the adult human liver, is
involved in the metabolism of approximately 50% of commonly prescribed drugs. Several …

CYP2C9 is a polymorphic enzyme that metabolizes a number of clinically important drugs.
In this study, catalytic activities of seven alleles found in Japanese individuals, CYP2C9*3 (…

Recently, the pharmaceutical industry has employed the high-throughput method for the
evaluation of cytochrome P450 (CYP) inhibition, using a combination of the heterologously …

Plasma concentration, distribution, and excretion of [14C]-alendronate were in vestigated
after repeated intravenous administration once a day for 7 days to 7-wee k old male rats and …

Plasma concentration, bone distribution, and excretion after single intravenous administration
of [14C]-alendronate to beagle dogs were investigated. 1. The levels of plasma …

The behaviors of alloying elements and their effects on hardenability were investigated for
quenched and tempered Fe-2.1 mass% C-5mass% Cr-5mass% Mo-5.5 mass% V-0/5mass% …

The ubiquitin ligase constitutively photomorphogenic 1 (COP1) is involved in many biological
responses in mammalian cells, but its role in tumorigenesis remains unclear. Here we …

Podocalyxin (PODXL) overexpression is associated with progression, metastasis, and poor
outcomes in cancers. We recently produced the novel anti-PODXL monoclonal antibody (…

C/EBPα is a key transcription factor regulating myeloid differentiation and leukemogenesis.
The Trib1-COP1 complex is an E3 ubiquitin ligase that targets C/EBPα for degradation, and …