Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced
hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that …

Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases worldwide, causing fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and …

BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (STAT3) is known
to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic …

Alcoholic and nonalcoholic steatohepatitis are characterized by fatty liver plus inflammation.
It is generally believed that steatosis promotes inflammation, whereas inflammation in turn …

Hepatocyte growth factor (HGF) is a mitogen for hepatocytes, but it is not clear whether HGF
stimulates or inhibits hepatocarcinogenesis. We previously reported that HGF transgenic …

OBJECTIVES: The aim of this study was to assess the long-term prognosis, efficacy, and
safety of combination therapy using ursodeoxycholic acid (UDCA) and bezafibrate (BF) for …

Liver fibrosis, or cirrhosis, is a common end-stage condition of many chronic liver diseases
after incomplete recovery from hepatocyte damage. During fibrosis progression, …

Aim Amino acid transporters play an important role in tumor progression and survival of
cancer cells. However, the prognostic significance of L ‐type amino acid transporter 1 ( LAT1 ), …

Background: Non-alcoholic fatty liver disease is a common liver injury, but the pathophysiological
mechanisms leading to the development of non-alcoholic steatohepatitis (NASH) …

Increasing evidence suggests that liver regeneration is suppressed in patients with chronic
HCV infection; however, the underlying mechanisms remain unclear. Previously, we …