DNA hypomethylation and unusual chromosome instability in cell lines fromICF syndrome patients

…, D Smeets, J Sawyer, ES Fiala, OS Sohn… - Cytogenetics and cell …, 2000 - karger.com
The ICF syndrome (i̲mmunodeficiency, c̲entromeric region instability, f̲acial anomalies)
is a unique DNA methylation deficiency disease diagnosed by an extraordinary collection of …

Chemoprevention of cancer by organoselenium compounds

…, P Upadhyaya, YH Chae, OS Sohn… - Journal of cellular …, 1995 - Wiley Online Library
A major research goal of our laboratories is the development of new organoselenium cancer
chemopreventive agents with less toxicity compared to some of the historical selenium …

Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol

OS Sohn, ES Fiala, SP Requeijo, JH Weisburger… - Cancer research, 2001 - AACR
… Ock Soon Sohn; Ock Soon Sohn … Fiala ES, Sohn OS, Puz C., Czerniak R. Differential effects
of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol …

Hypomethylation and hypermethylation of DNA in Wilms tumors

…, E Fiala, JS Dome, MC Yu, TI Long, B Youn, OS Sohn… - Oncogene, 2002 - nature.com
We quantitatively analysed hypermethylation at CpG islands in the 5′ ends of 12 genes
and one non-CpG island 5′ region (MTHFR) in 31 Wilms tumors. We also determined their …

Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1

OS Sohn, H Ishizaki, CS Yang, ES Fiala - Carcinogenesis, 1991 - academic.oup.com
OSSohn et at. … OSSohn et at. … OS and Fiala.ES (1988) Formation of methylphosphate during
the metabolic activation of methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA…

Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat

OS Sohn, A Surace, ES Fiala, JP Richie, S Colosimo… - Xenobiotica, 1994 - Taylor & Francis
1. The induction of phase I and II enzymes in the liver of the male F344 rat drinking 2% (w/v)
solutions of green or black tea for 6 weeks was investigated. Also studied were glutathione (…

Effects of Chronic Dietary Ethanol on in Vivo and in Vitro Metabolism of Methylazoxymethanol and on Methylazoxymethanol-induced DNA Methylation in Rat Colon …

ES Fiala, OS Sohn, SR Hamilton - Cancer research, 1987 - AACR
We examined the metabolism of 14 C-labeled methylazoxymethanol (MAM) in male F344
rats pair-fed for 21.0 days either a liquid control diet, an isocaloric liquid diet containing 6.6% …

Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats

ES Fiala, C Joseph, OS Sohn, K El-Bayoumy… - Cancer research, 1991 - AACR
Benzylselenocyanate (BSC), a novel organoselenium compound, has been found to inhibit
azoxymethane (AOM)-induced colon carcinogenesis in rats during initiation. To investigate …

Chemoprevention of lung tumorigenesis induced by a mixture of benzo (a) pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium …

B Prokopczyk, JG Rosa, D Desai, S Amin, OS Sohn… - Cancer letters, 2000 - Elsevier
We evaluated the chemopreventive efficacy of the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate
(p-XSC) against the development of tumors of the lung and …

Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E

ES Fiala, OS Sohn, CX Wang, E Seibert… - …, 2005 - academic.oup.com
The development of effective chemopreventive agents against cigarette smoke-induced lung
cancer could be greatly facilitated by the availability of suitable laboratory animal models. …