User profiles for O Van Tellingen

Olaf van Tellingen

Netherlands Cancer Institute
Verified email at nki.nl
Cited by 24438

The pharmacological role of P-glycoprotein in the intestinal epithelium

J VAN ASPEREN, OH VAN TELLINGEN… - Pharmacological …, 1998 - Elsevier
P-glycoprotein, a membrane-associated transport protein, has recently been recognised as
an important element of the intestinal epithelium. This paper summarises thein vivodata on …

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

O Van Tellingen, B Yetkin-Arik, MC De Gooijer… - Drug Resistance …, 2015 - Elsevier
… prevents efficient passage of cancer … of the BBTB in glioma patients and preclinical models
and discuss the advantages and drawbacks of drug delivery approaches for the treatment of

[HTML][HTML] Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

…, MA van der Valk, O van Tellingen… - The Journal of …, 2007 - Am Soc Clin Investig
of more than half of all prescribed medications. To investigate the physiological and
pharmacological roles of … To determine the relative importance of intestinal versus hepatic Cyp3a …

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

…, JH Beijnen, O Van Tellingen - Proceedings of the …, 1997 - National Acad Sciences
… limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the … of
10–200 μl of plasma, bile, and homogenates of intestinal contents were also added to 3 ml of

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

AH Schinkel, JJM Smit, O van Tellingen, JH Beijnen… - Cell, 1994 - cell.com
… Our findings explain some of the side effects in patients treated with a combination of … these
inhibitors might be useful in selectively enhancing the access of a range of drugs to the brain. …

Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C

…, JM Lakhai, M Van Der Valk, O Van Tellingen… - Molecular cancer …, 2002 - AACR
… in functional assays of BCRP … of BCRP, but its neurotoxic effects preclude use in vivo. We
have therefore evaluated a new tetracyclic analogue of FTC, Ko143, as a practical inhibitor of

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

…, J Lankelma, O vAN Tellingen… - Proceedings of the …, 1995 - National Acad Sciences
of MRP to the intracellular supply of GSH. This link doesnot appear to be the result of an indirect
effect of … The cloning efficiency of SW-1573 cells decreased only 15% by incubation with …

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

…, KG Gilhuijs, O Van Tellingen… - Proceedings of the …, 2007 - National Acad Sciences
… the promise of these mouse tumors for the study of tumor-initiating cells and of drug therapy
of … Analysis of tumor samples from patients and of tumor cell lines selected for resistance in …

[HTML][HTML] Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

JW Smit, MT Huisman, O van Tellingen… - The Journal of …, 1999 - Am Soc Clin Investig
of placental drug-transporting P-gp in toxicological protection of the fetus, we used mice with
a targeted disruption of … +/– /1b +/– males to obtain fetuses of 3 genotypes (Mdr1a +/+ /1b +/…

… Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance …

…, D Pluim, G Cipriani, P Wielinga, O van Tellingen… - Cancer research, 2005 - AACR
of BCRP and P-gp inhibitors may improve delivery of imatinib to malignant gliomas. … effect
of imatinib mesylate on the transport of 100 μmol/L MTX. The ATP-dependent transport of MTX …