Background: Cyclophosphamide, which forms the nucleus for virtually all preparative
regimens for autologous bone marrow transplantation (ABMT), is an alkylating cagent of which …

The anticancer prodrug ifosfamide (IFA) contains a chiral phosphorous atom and is
administered clinically as a racemic mixture ofR and S enantiomers. Animal model studies and …

4-Hydroperoxycyclophosphamide is an oxazaphosphorine which is readily converted
without enzymatic involvement to 4-hydroxycyclophosphamide – a key intermediate in the …

An autologous bone marrow transplant regimen of ifosfamide, carboplatin, and etoposide (ICE)
has been developed as treatment for certain malignancies. At maximum tolerated doses …

Cyclophosphamide is a prodrug activated by cytochrome P450 isozymes in the liver. The
product of hepatic activation of cyclophosphamide is 4-hydroxycyclophosphamide. Previously …

Dose Escalation of N,N’,N’ ‘-Triethylenethiophosphoramide Combined with Pentoxifylline for
Advanced Breast Cancer1 Page 1 Vol. 1, 791-796, August 1995 Clinical Cancer Research …

An epoxy resin modified with polysulfone (PSU) and active diluent furfuryl glycidyl ether (FGE)
was studied. Triethanolaminotitanate (TEAT) and iso-methyltetrahydrophthalic anhydride (…

Glycero-(9,10-trioxolane)-trioleate (ozonide of oleic acid triglyceride, OTOA) was introduced
into polylactic acid (PLA) films in amounts of 5, 10, 30, 50, and 70% w/w. The morphological, …

The crystals of heterospin complexes [M(hfac) 2 L 2 ] (where M = Cu, Ni, Co, or Mn; hfac =
hexafluoroacetylacetonate; and L = nitronyl nitroxide, 4,4,5,5-tetramethyl-2-(1-methyl-1H-…

An effective method for the synthesis of 4,4,5,5-tetramethyl-3-oxide-1-oxyl-4,5-dihydro-1H-imidazole-2-carbonitrile
(1) has been found. 4,4,5,5-Tetramethyl-3-oxide-1-oxyl-4,5-dihydro-…