Background Recent years have witnessed that there is a revival of interest in drug discovery
from medicinal plants for the maintenance of health in all parts of the world. The aim of this …

The development of photoactivatable prodrugs of platinum-based antitumor agents is aimed
at increasing the selectivity and hence lowering toxicity of this important class of antitumor …

Multinuclear platinum anticancer complexes are a proven option to overcome resistance of
established anticancer compounds. Transferring this concept to ruthenium complexes led to …

Ru II (arene) complexes have been shown to be promising anticancer agents, capable of
overcoming major drawbacks of currently used chemotherapeutics. We have synthesized Ru II (…

A series of novel C,N-cyclometalated benzimidazole ruthenium(II) and iridium(III) complexes
of the types [(η 6 -p-cymene)RuCl(κ 2 -N,C-L)] and [(η 5 -C 5 Me 5 )IrCl(κ 2 -N,C-L)] (HL = …

An original approach intended to facilitate the intratumoral activation of Pt(IV) diamines by
illumination with visible light to form photolysis products that irreversibly bind to DNA and are …

A series of Cu(II) coordination compounds with benzimidazole-derived bidentate chelating
ligands have been prepared and characterized by X-ray crystallography. The 2-(4,5-dihydro-…

Seven recalcitrant pharmaceutical residues (diclofenac, 17α-ethinylestradiol, carbamazepine,
ibuprofen, trimethoprim, diazepam, diatrizoate) were decomposed by pulsed corona …

A possible way to avoid dose-limiting side effects of platinum anticancer drugs is to employ
light to cause photochemical changes in nontoxic platinum prodrugs that release active …

The aim of this work was 2-fold:(i) to identify correlations between the activities of pairs of 19
anti-tumor agents in a mini-panel of 14 human cancer cell lines of diverse origins with the …