Cancer develops through a process of somatic evolution 1 , 2 . Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

With the emergence of individualized medicine and the increasing amount and complexity
of available medical data, a growing need exists for the development of clinical decision-…

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole-genome …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Background Visualization of orthogonal (disjoint) or overlapping datasets is a common task
in bioinformatics. Few tools exist to automate the generation of extensively-customizable, …

Meningiomas are the most common primary intracranial tumour in adults 1 . Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …

Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …