Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of
rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The …

Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma
burden in rodent models of colorectal cancer accompanied by a reduction of levels of the …

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in
epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and …

Over the past 40 years considerable emphasis has been placed on the development of accurate
and sensitive methods for the detection and quantitation of DNA adducts. The formation …

Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are promising cancer chemopreventive
agents in rodent models, but there is a paucity of data on their pharmacokinetics and …

Exposure to high levels of environmental air pollution is known to be associated with an
increased carcinogenic risk. The individual contribution to this risk derived from specific …

Evidence is presented in support of the following metabolic pathways, in the liver, of the
antitumour agent cyclophosphamide 2-[bis(2-chloroethyl)amino]-tetrahydro-2H-1,3,2-…

Silibinin, a flavonolignan from milk thistle, has intestinal cancer chemopreventive efficacy in
rodents. It is a strong antioxidant and modulates the insulin-like growth factor (IGF) system by …

Aims: Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is a widely used biomarker
of oxidative stress. However, variability between chromatographic and ELISA methods …

Many studies using mammalian cellular and subcellular systems have demonstrated that
polycyclic aromatic hydrocarbons, including benzo[ a ]pyrene (BaP), are metabolically …