Optimization of the imidazo[4,5-b]pyridine-based series of Aurora kinase inhibitors led to the
identification of 6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-…

with 2-methoxypropene16 in CCU in the presence of a trace of phosphorus oxychloride and
exposed to 3 equiv of lithium acetylide-ethylenediamine complex in dimethyl sulfoxide at 25 …

Five 1-benzazepine heterocycles were synthesized by utilizing transition-metal-catalyzed
processes in key bond-forming steps. exo-Methylene and methyl substituents were introduced …

These results indicated that theadenine ring was constituted from two molecules of formamide
and three molecules of hydrogen cyanide. Among the CN units in adenine, C5-N7, Ce-…

Abstract Treatment of N, N-diformylaminomethyl aryl ketones with phosphorus pentasulfide/triethylamine
in chloroform gives 5-arylthiazoles directly in good yield. The 5-aryl-1, 3-…

Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method
of preparation is available. We describe here a high-yielding method for the synthesis of …

A synthetic route to 1-benzyl-tetrahydro-1-benzazepine is reported, which also permits access
to analogous structures with alkyl and aryl substituents at position-2 of the aliphatic ring. …

Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in the regulation of Ca 2+
release from inositol 1,4,5-triphosphate-sensitive stores. U73122 (1-(6-((17β-3-…

Partially and fully reduced forms of benzo-fused eight- to ten-membered nitrogen
heterocycles (1-benzazecines, 1-benzazonines and 1-benzazecines) have been prepared. …

An efficient synthesis of a 1, 4-benzodiazepine was accomplished using copper catalysed
amination of an arylbromide with the soluble bis-tetrabutylammonium salt of L-aspartic acid …