User profiles for Philip Breen
Phil BreenUniversity of Edinburgh Verified email at ed.ac.uk Cited by 843 |
Cyclodextrins in pharmaceutical formulations I: Structure and physicochemical properties, formation of complexes, and types of complex
SS Jambhekar, P Breen - Drug discovery today, 2016 - Elsevier
Highlights • Cyclodextrins and the complexes they form are described. • Pharmaceutical
uses of cyclodextrin are enumerated. • Physical chemical properties of cyclodextrins are …
uses of cyclodextrin are enumerated. • Physical chemical properties of cyclodextrins are …
[HTML][HTML] A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
Genome-wide association studies (GWAS) have identified thousands of genomic regions
affecting complex diseases. The next challenge is to elucidate the causal genes and …
affecting complex diseases. The next challenge is to elucidate the causal genes and …
[BOOK][B] Basic pharmacokinetics
SS Jambhekar, PJ Breen - 2009 - toc.library.ethz.ch
… Philip J. Breen PhD Associate Professor, Department of Pharmaceutical Sciences, College
of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA …
of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA …
Dynamical evolution of black hole subsystems in idealized star clusters
PG Breen, DC Heggie - Monthly Notices of the Royal …, 2013 - academic.oup.com
In this paper, globular star clusters which contain a subsystem of stellar mass black holes (BH)
are investigated. This is done by considering two-component models, as these are the …
are investigated. This is done by considering two-component models, as these are the …
Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency
SS Jambhekar, P Breen - Drug discovery today, 2016 - Elsevier
Highlights • Determination and significance of the binding constant is described. • The
complexation efficiency and its utility are discussed. • The use of cyclodextrin in the solubilization …
complexation efficiency and its utility are discussed. • The use of cyclodextrin in the solubilization …
Newton versus the machine: solving the chaotic three-body problem using deep neural networks
Since its formulation by Sir Isaac Newton, the problem of solving the equations of motion for
three bodies under their own gravitational force has remained practically unsolved. Currently…
three bodies under their own gravitational force has remained practically unsolved. Currently…
Drug dissolution: significance of physicochemical properties and physiological conditions
SS Jambhekar, PJ Breen - Drug Discovery Today, 2013 - Elsevier
Highlights • Drug dissolution theories used to describe drug dissolution. • Influence of
physicochemical properties of a drug on dissolution. • Influence of physiological conditions on drug …
physicochemical properties of a drug on dissolution. • Influence of physiological conditions on drug …
The microcirculation of the bone marrow
PPH De Bruyn, PC Breen… - The Anatomical Record, 1970 - Wiley Online Library
The microcirculation in the bone marrow has been studied in the femur, tibia, and humerus
of guinea pigs, rats, and rabbits. Used were whole mounts of bone with bone marrow in situ, …
of guinea pigs, rats, and rabbits. Used were whole mounts of bone with bone marrow in situ, …
Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to …
…, J Thaden, Y Tong, WB Gentry, P Breen… - The Journal of …, 2006 - Wiley Online Library
Phytochemical‐mediated modulation of cytochrome P450 enzymes (CYPs) may underlie
many herb‐drug interactions. This study's purpose was to assess the effects of milk thistle and …
many herb‐drug interactions. This study's purpose was to assess the effects of milk thistle and …
Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
…, GW Barone, DK Williams, J Carrier, P Breen… - Drug metabolism and …, 2006 - ASPET
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters
may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp …
may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp …