Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

…, P Korprasertthaworn… - British journal of …, 2018 - Wiley Online Library
Aim The aim of the present study was to predict olanzapine (OLZ) exposure in individual
patients using physiologically based pharmacokinetic modelling and simulation (PBPK M&S). …

In vitro characterization of the human liver microsomal kinetics and reaction phenotyping of olanzapine metabolism

P Korprasertthaworn, TM Polasek, MJ Sorich… - Drug Metabolism and …, 2015 - ASPET
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and
related psychoses. The metabolism of OLZ is complex and incompletely characterized. This …

Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors: effects of dabrafenib, ibrutinib, nintedanib, trametinib and BIBF 1202

P Korprasertthaworn, N Chau, PC Nair… - Biochemical …, 2019 - Elsevier
We have demonstrated previously that the kinase inhibitors (KIs) lapatinib, pazopanib,
regorafenib and sorafenib are potent inhibitors of UGT1A1 and UGTs 1A7-1A10. The present …

Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity

P Korprasertthaworn, A Rowland, BC Lewis… - Biochemical …, 2012 - Elsevier
UGT1A9 contributes to the glucuronidation of numerous drugs and xenobiotics. There is
evidence to suggest that the Met33Thr substitution, as occurs in the polymorphic variant …

[HTML][HTML] Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib

…, P Yamanont, D Pinthong, P Korprasertthaworn - Toxicology Reports, 2022 - Elsevier
Herbal products are widely used in cancer patients via co−administration with chemotherapy.
Previous studies have demonstrated that pharmacokinetic interactions between herbs and …

Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy

BC Lewis, P Korprasertthaworn… - Pharmacogenetics and …, 2016 - journals.lww.com
Objectives To extend our understanding of how interindividual variability mediates the
efficacy of cancer treatment. Materials and methods The kinetics of dacarbazine (DTIC) N-…

Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population

P Korprasertthaworn, W Udomuksorn… - Drug metabolism and …, 2009 - jstage.jst.go.jp
The human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various
endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of …

In Vitro Characterization of Human Liver Microsomal Kinetics and Enzyme Involvement in Olanzapine Metabolism

P Korprasertthaworn, TM Polasek, MJ Sorich… - Drug Metabolism and …, 2015 - ASPET
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and
related psychoses. The metabolism of OLZ is complex and incompletely characterized. The aim …

[CITATION][C] The human UDP-glucuronosyltransferase enzyme inhibition selectivity of nintedanib and its de-esterified metabolite BIBF1202

P Korprasertthaworn, A Rowland, K Burns… - Drug Metabolism and …, 2017 - cir.nii.ac.jp
Porntipa Korprasertthaworn

[CITATION][C] In vitro characterisation of the'albumin effect'on human liver microsomal olanzapine oxidative metabolism

P Korprasertthaworn, A McLachlan… - 46th ASCEPT …, 2012 - researchnow.flinders.edu.au
Porntipa Korprasertthaworn, Andrew McLachlan, Metodey Polasek, John Miners, Andrew
Rowland …