Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation
…, P Korprasertthaworn… - British journal of …, 2018 - Wiley Online Library
Aim The aim of the present study was to predict olanzapine (OLZ) exposure in individual
patients using physiologically based pharmacokinetic modelling and simulation (PBPK M&S). …
patients using physiologically based pharmacokinetic modelling and simulation (PBPK M&S). …
In vitro characterization of the human liver microsomal kinetics and reaction phenotyping of olanzapine metabolism
P Korprasertthaworn, TM Polasek, MJ Sorich… - Drug Metabolism and …, 2015 - ASPET
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and
related psychoses. The metabolism of OLZ is complex and incompletely characterized. This …
related psychoses. The metabolism of OLZ is complex and incompletely characterized. This …
Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors: effects of dabrafenib, ibrutinib, nintedanib, trametinib and BIBF 1202
We have demonstrated previously that the kinase inhibitors (KIs) lapatinib, pazopanib,
regorafenib and sorafenib are potent inhibitors of UGT1A1 and UGTs 1A7-1A10. The present …
regorafenib and sorafenib are potent inhibitors of UGT1A1 and UGTs 1A7-1A10. The present …
Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity
UGT1A9 contributes to the glucuronidation of numerous drugs and xenobiotics. There is
evidence to suggest that the Met33Thr substitution, as occurs in the polymorphic variant …
evidence to suggest that the Met33Thr substitution, as occurs in the polymorphic variant …
[HTML][HTML] Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib
…, P Yamanont, D Pinthong, P Korprasertthaworn - Toxicology Reports, 2022 - Elsevier
Herbal products are widely used in cancer patients via co−administration with chemotherapy.
Previous studies have demonstrated that pharmacokinetic interactions between herbs and …
Previous studies have demonstrated that pharmacokinetic interactions between herbs and …
Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy
BC Lewis, P Korprasertthaworn… - Pharmacogenetics and …, 2016 - journals.lww.com
Objectives To extend our understanding of how interindividual variability mediates the
efficacy of cancer treatment. Materials and methods The kinetics of dacarbazine (DTIC) N-…
efficacy of cancer treatment. Materials and methods The kinetics of dacarbazine (DTIC) N-…
Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population
P Korprasertthaworn, W Udomuksorn… - Drug metabolism and …, 2009 - jstage.jst.go.jp
The human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various
endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of …
endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of …
In Vitro Characterization of Human Liver Microsomal Kinetics and Enzyme Involvement in Olanzapine Metabolism
P Korprasertthaworn, TM Polasek, MJ Sorich… - Drug Metabolism and …, 2015 - ASPET
Olanzapine (OLZ) is an atypical antipsychotic used in the treatment of schizophrenia and
related psychoses. The metabolism of OLZ is complex and incompletely characterized. The aim …
related psychoses. The metabolism of OLZ is complex and incompletely characterized. The aim …
[CITATION][C] The human UDP-glucuronosyltransferase enzyme inhibition selectivity of nintedanib and its de-esterified metabolite BIBF1202
P Korprasertthaworn, A Rowland, K Burns… - Drug Metabolism and …, 2017 - cir.nii.ac.jp
… Porntipa Korprasertthaworn …
[CITATION][C] In vitro characterisation of the'albumin effect'on human liver microsomal olanzapine oxidative metabolism
P Korprasertthaworn, A McLachlan… - 46th ASCEPT …, 2012 - researchnow.flinders.edu.au
… Porntipa Korprasertthaworn, Andrew McLachlan, Metodey Polasek, John Miners, Andrew
Rowland …
Rowland …