Current methodologies used for evaluation of intestinal permeability and absorption
PV Balimane, S Chong, RA Morrison - Journal of pharmacological and …, 2000 - Elsevier
This review article will focus on the various techniques that are currently employed by drug
discovery scientists in evaluating permeability/absorption of drug candidates during the drug …
discovery scientists in evaluating permeability/absorption of drug candidates during the drug …
Cell culture-based models for intestinal permeability: a critique
PV Balimane, S Chong - Drug discovery today, 2005 - Elsevier
The model systems that are currently used to determine the intestinal permeability characteristics
of discovery compounds often represent a combination of high-throughout, but less …
of discovery compounds often represent a combination of high-throughout, but less …
Current industrial practices of assessing permeability and P-glycoprotein interaction
PV Balimane, YH Han, S Chong - The AAPS journal, 2006 - Springer
Combination of the in vitro models that are high throughput but less predictive and the in
vivo models that are low throughput but more predictive is used effectively to evaluate the …
vivo models that are low throughput but more predictive is used effectively to evaluate the …
A novel design of artificial membrane for improving the PAMPA model
…, A Murawski, K Patel, CL Crespi, PV Balimane - Pharmaceutical …, 2008 - Springer
Purpose Since the first demonstration of PAMPA, the artificial membrane has been traditionally
prepared by impregnating a porous filter with a solution of lipid mixture. While the lipid …
prepared by impregnating a porous filter with a solution of lipid mixture. While the lipid …
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
PV Balimane, I Tamai, A Guo, T Nakanishi… - Biochemical and …, 1998 - Elsevier
Xenopus laevisoocytes were used as a gene expression system to characterize the carrier-mediated
transport of valacyclovir (vacv), the L-valine ester prodrug of the acyclic nucleoside …
transport of valacyclovir (vacv), the L-valine ester prodrug of the acyclic nucleoside …
Pharmacokinetic drug interactions involving 17α-ethinylestradiol: a new look at an old drug
H Zhang, D Cui, B Wang, YH Han, P Balimane… - Clinical …, 2007 - Springer
17α-Ethinylestradiol (EE) is widely used as the estrogenic component of oral contraceptives
(OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, …
(OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, …
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk …
…, YA Pak, ES Perloff, E Reyner, P Balimane… - Drug metabolism and …, 2013 - ASPET
A P-glycoprotein (P-gp) IC 50 working group was established with 23 participating
pharmaceutical and contract research laboratories and one academic institution to assess …
pharmaceutical and contract research laboratories and one academic institution to assess …
Characterization of efflux transporters involved in distribution and disposition of apixaban
The studies reported here were conducted to investigate the transport characteristics of
apixaban (1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-…
apixaban (1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-…
Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity
…, R Attar, B Balasubramanian, P Balimane… - Journal of medicinal …, 2005 - ACS Publications
… Praveen Balimane … Praveen Balimane - Discovery Chemistry, Department of
Metabolism and Pharmacokinetics, Department of Computer Aided Drug Design, and …
Metabolism and Pharmacokinetics, Department of Computer Aided Drug Design, and …
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line
A Guo, P Hu, PV Balimane, FH Leibach… - Journal of Pharmacology …, 1999 - ASPET
The results of previous work performed in our laboratory using an in situ perfusion technique
in rats and rabbit apical brush border membrane vesicles have suggested that the intestinal …
in rats and rabbit apical brush border membrane vesicles have suggested that the intestinal …