User profiles for Priyadeep Bhutani
 | Priyadeep bhutaniVerified email at jubilantbiosys.com Cited by 496 |
US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the drugs …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the drugs …
Targeting the epidermal growth factor receptor with molecular degraders: State-of-the-art and future opportunities
Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical
role in several cellular functions including cancer cell growth, survival, proliferation, …
role in several cellular functions including cancer cell growth, survival, proliferation, …
Design, synthesis, and pharmacokinetic evaluation of phosphate and amino acid ester prodrugs for improving the oral bioavailability of the HIV-1 protease inhibitor …
…, S Sridhar, S Padmanabhan, P Bhutani… - Journal of Medicinal …, 2019 - ACS Publications
Phosphate and amino acid prodrugs of the HIV-1 protease inhibitor (PI) atazanavir (1) were
prepared and evaluated to address solubility and absorption limitations. While the …
prepared and evaluated to address solubility and absorption limitations. While the …
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models
In recent years prodrug strategy has been used extensively to improve the pharmacokinetic
properties of compounds exhibiting poor bioavailability. Mechanistic understanding of the …
properties of compounds exhibiting poor bioavailability. Mechanistic understanding of the …
Coupling of an acyl migration prodrug strategy with bio-activation to improve oral delivery of the HIV-1 protease inhibitor atazanavir
…, S Sridhar, S Padmanabhan, P Bhutani… - Journal of Medicinal …, 2018 - ACS Publications
HIV-1 protease inhibitors (PIs), which include atazanavir (ATV, 1), remain important medicines
to treat HIV-1 infection. However, they are characterized by poor oral bioavailability and a …
to treat HIV-1 infection. However, they are characterized by poor oral bioavailability and a …
Structural Rationalization for the Nonmutagenic and Mutagenic Bypass of the Tobacco-Derived O4-4-(3-Pyridyl)-4-oxobut-1-yl-thymine Lesion by Human Polymerase …
P Bhutani, MT Murray, CW Sommer… - Chemical Research …, 2021 - ACS Publications
Tobacco-derived pyridyloxobutyl (POB) DNA adducts are unique due to the large size and
flexibility of the alkyl chain connecting the pyridyl ring to the nucleobase. Recent experimental …
flexibility of the alkyl chain connecting the pyridyl ring to the nucleobase. Recent experimental …
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of …
…, S Sridhar, S Padmanabhan, P Bhutani… - Journal of Medicinal …, 2022 - ACS Publications
Structure–property relationships associated with a series of (carbonyl)oxyalkyl amino acid
ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance …
ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance …
(Carbonyl) oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration
…, S Sridhar, S Padmanabhan, P Bhutani… - European Journal of …, 2020 - Elsevier
We describe the design, synthesis and pharmacokinetic (PK) evaluation of a series of
amino acid-based prodrugs of the HIV-1 protease inhibitor atazanavir (1) derivatized on the …
amino acid-based prodrugs of the HIV-1 protease inhibitor atazanavir (1) derivatized on the …
Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats
…, P Katnapally, R Nutakki, S Paruchury, P Bhutani… - Xenobiotica, 2014 - Taylor & Francis
The effect of age and obesity on the pharmacokinetics (PK), hepatic blood flow (HBF) and
liver metabolism of 10 compounds was determined in rats. The animals fed a high-fat diet …
liver metabolism of 10 compounds was determined in rats. The animals fed a high-fat diet …
Rapid and cost‐effective LC–MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial …
Garcinia cambogia is one of the most commonly used anti‐obesity dietary supplements, and
hydroxycitric acid (HCA) is a major constituent in the commercial preparations of Garcinia. …
hydroxycitric acid (HCA) is a major constituent in the commercial preparations of Garcinia. …