Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence

GX Hu, QQ Lian, RS Ge, DO Hardy, XK Li - Trends in Endocrinology & …, 2009 - cell.com
Phthalates, the most abundantly produced plasticizers, leach out from polyvinyl chloride
plastics and disrupt androgen action. Male rats that are exposed to phthalates in utero develop …

Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero

…, GR Chen, GX Hu, L Dong, QQ Lian… - Proceedings of the …, 2008 - National Acad Sciences
Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with
decreased adult testosterone (T) levels and increased Leydig cell numbers. As yet, little is …

Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells

…, HX Chen, HQ Yu, Y Liang, C Wang, QQ Lian… - Experimental cell …, 2010 - Elsevier
Bone remodeling relies on a dynamic balance between bone formation and resorption,
mediated by osteoblasts and osteoclasts, respectively. Under certain stimuli, osteoprogenitor …

Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2

X Ma, QQ Lian, Q Dong, RS Ge - Toxicology, 2011 - Elsevier
11β-Hydroxysteroid dehydrogenase (11β-HSD) regulates glucocorticoid action by
catalyzing the interconversion of active cortisol and inactive cortisone in glucocorticoid and …

[HTML][HTML] Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats

GX Hu, H Lin, QQ Lian, SH Zhou, J Guo, HY Zhou… - PLoS …, 2013 - journals.plos.org
Background 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates glucocorticoid
locally in liver and fat tissues to aggravate metabolic syndrome. 11β-HSD1 selective inhibitor …

Rapid mechanisms of glucocorticoid signaling in the Leydig cell

GX Hu, QQ Lian, H Lin, SA Latif, DJ Morris, MP Hardy… - Steroids, 2008 - Elsevier
Stress-mediated elevations in circulating glucocorticoid levels lead to corresponding rapid
declines in testosterone production by Leydig cells in the testis. In previous studies we have …

[HTML][HTML] In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach

H Lin, K Yuan, L Li, S Liu, S Li, G Hu, QQ Lian… - International Journal of …, 2015 - mdpi.com
Diethylhexyl phthalate (DEHP) is one of the most widely utilized phthalate plasticizers.
Previous studies have demonstrated that gestational or postnatal DEHP exposure induced …

Lipoxin A4 Activates Alveolar Epithelial Sodium Channel, Na,K-ATPase, and Increases Alveolar Fluid Clearance

Q Wang, QQ Lian, R Li, BY Ying, Q He… - American journal of …, 2013 - atsjournals.org
Edema fluid resorption is critical for gas exchange, and both alveolar epithelial sodium
channel (ENaC) and Na,K-ATPase are accredited with key roles in the resolution of pulmonary …

Deletion of the Igf1 Gene: Suppressive Effects on Adult Leydig Cell Development

GX Hu, H Lin, GR Chen, BB Chen, QQ Lian… - Journal of …, 2010 - Wiley Online Library
Deletion of the insulin‐like growth factor 1 (Igf1) gene was shown in previous studies to
result in reduced numbers of Leydig cells in the testes of 35‐day‐old mice, and in reduced …

The effect of labor epidural analgesia on maternal–fetal outcomes: a retrospective cohort study

…, SX Zheng, YF Ni, YY Lu, B Zhang, QQ Lian… - Archives of gynecology …, 2018 - Springer
Purpose To evaluate the impact of labor epidural analgesia on maternal–fetal safety outcomes
in a signal Chinese academic medical center. Methods A single-intervention impact study …