Ribonucleotide reductase consists of two nonidentical subunits, proteins R1 and R2, the latter
of which contains an iron-tyrosyl free radical center essential for activity. We have studied …

We have investigated the induction of an important polyamine metabolic enzyme,
spermidine/spermine N 1 -acetyltransferase, in two human lung cancer cell lines which respond …

Earlier this year, I remarked in a review of another book that chemists tend to write very
different books about enzymes from those written by biochemists, often concentrating on what …

In this paper, we report on the synthesis and biological activity of a number of N-alkylated
spermine compounds. The dialkylspermines ATl, N12-dimethylspermine (DMSPM-2), N/A'^-…

… Porter, CW, and Bergeron, RJ Enzyme regulation as an … Porter, CW, and Bergeron, RJ
Regulation of polyamine biosynthetic … RJ, and Bergeron, RJ Regulation of polyamine biosynthetic …

Desferrithiocin, a novel microbial siderophore isolated from cultures of Streptomyces antibioticus
DSM 1865, and a number of its derivatives and analogues are evaluated fortheir ability …

A series of iron chelating agents including the bacterial siderophores, parabactin and bis-N
1 ,N 8 (2,3 dihydroxybenzoyl) spermidine, and four related compounds were synthesized …

The extent to which cyclohexaamylose binds p-nitrophenol, 2, 6-dimethyl-4-nitrophenol, 3, 5-dimethyl-4-nitrophenol,
3-methyl-4-nitrophenol, and their correspondingsodium phenolates …

Representing an integration of basic and clinical sciences, this book focuses on new concepts
in the design, synthesis, and testing of iron chelators for clinical application. It provides an …

A systematic investigation of the impact of spermidine analogues both in vitro and in vivo is
described. The study characterizes the effects of these analogues on L1210 cell growth, …