DT-diaphorase and cancer chemotherapy
RJ Riley, P Workman - Biochemical pharmacology, 1992 - Elsevier
The first report documenting the discovery of DT-diaphorase, nowadays more properly
referred to as NAD (P) H:(quinone acceptor) oxidoreductase (EC 1.6. 99.2)'~, was published in …
referred to as NAD (P) H:(quinone acceptor) oxidoreductase (EC 1.6. 99.2)'~, was published in …
The pivotal role of hepatocytes in drug discovery
MG Soars, DF McGinnity, K Grime, RJ Riley - Chemico-biological …, 2007 - Elsevier
This review promotes the value of isolated hepatocytes in modern Drug Discovery programmes
and outlines how increased understanding, particularly in the area of in vitro–in vivo …
and outlines how increased understanding, particularly in the area of in vitro–in vivo …
Collecting and analyzing cord blood gases
RJ RILEY, JWC JOHNSON - Clinical obstetrics and gynecology, 1993 - journals.lww.com
… RILEY, MD … RILEY, MD … RILEY, MD …
A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes
RJ Riley, DF McGinnity, RP Austin - Drug Metabolism and Disposition, 2005 - ASPET
The aim of this study was to evaluate a unified method for predicting human in vivo intrinsic
clearance (CL int, in vivo ) and hepatic clearance (CL h ) from in vitro data in hepatocytes …
clearance (CL int, in vivo ) and hepatic clearance (CL h ) from in vitro data in hepatocytes …
The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties
…, P Barton, SL Cockroft, MC Wenlock, RJ Riley - Drug Metabolism and …, 2002 - ASPET
The apparent intrinsic clearance of 13 drugs has been determined using rat liver microsomes
at three different concentrations of microsomal protein. The kinetics was studied using the …
at three different concentrations of microsomal protein. The kinetics was studied using the …
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance
…, MG Soars, RA Urbanowicz, RJ Riley - Drug metabolism and …, 2004 - ASPET
The intrinsic clearances (CL int ) of 50 neutral and basic marketed drugs were determined
in fresh human hepatocytes and the data used to predict human in vivo hepatic metabolic …
in fresh human hepatocytes and the data used to predict human in vivo hepatic metabolic …
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
…, G Pairaudeau, A Patel, AJ Rigby, RJ Riley… - Bioorganic & medicinal …, 2007 - Elsevier
Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y 12
receptor antagonists and exploitation of their SAR is described. Modifications of the acidic side …
receptor antagonists and exploitation of their SAR is described. Modifications of the acidic side …
Instability of thermocapillary–buoyancy convection in shallow layers. Part 1. Characterization of steady and oscillatory instabilities
RJ Riley, GP Neitzel - Journal of Fluid Mechanics, 1998 - cambridge.org
Combined thermocapillary–buoyancy convection in a thin rectangular geometry is investigated
experimentally, with an emphasis on the generation of hydrothermal-wave instabilities. …
experimentally, with an emphasis on the generation of hydrothermal-wave instabilities. …
In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance
MG Soars, B Burchell, RJ Riley - Journal of Pharmacology and Experimental …, 2002 - ASPET
The glucuronidation of a number of commonly used hepatic uridine diphosphate
glucuronosyltransferase drug substrates has been studied in human tissue microsomes. Prediction …
glucuronosyltransferase drug substrates has been studied in human tissue microsomes. Prediction …
Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis
M Civelek, E Manduchi, RJ Riley… - Circulation …, 2009 - Am Heart Assoc
Rationale: Endothelial function and dysfunction are central to the focal origin and regional
development of atherosclerosis; however, an in vivo endothelial phenotypic footprint of …
development of atherosclerosis; however, an in vivo endothelial phenotypic footprint of …