The objective of this review is to survey the recent literature regarding the various applications
of microdialysis in pharmacokinetics. Microdialysis is a relatively new technique for …

A general approach to the establishment of dosing regimens for drug administration by
multiple intravenous infusions is presented. The method is applicable where the elimination …

Many decisions in drug development and medical practice are based on measuring blood
concentrations of endogenous and exogenous molecules. Yet most biochemical and …

Multiple‐infusion dosing regimens for gentamicin were established for 84 patients with the
use of individually calculated values of elimination kinetic parameters. Serum level‐time data …

Studies of the pharmacokinetics of vancomycin were conducted in a group of 28 patients
with serious staphylococcal infection. Serum specimens were collected before and on 11 …

… Wang, and RJ Sawchuk. Analysis of zidovudine distribution … Wang, SL Wong, and RJ
Sawchuk. Comparison of in vitro … Wang, and RJ Sawchuk. Com parative delivery and distribution …

Two patients with extremely high blood methanol concentrations (260 and 282 mg/dl) were
successfully treated using pharmacokinetic dosing of ethanol, hemodialysis and supportive …

Quantitative microdialysis in the central nervous system (CNS) has recently provided evidence
for the existence of transporters as they relate to the brain distribution of a variety of drugs…

The distribution of currently available anti-HIV drugs into the CNS is reviewed with a focus
on transport mechanisms. Among these drugs, nucleoside analogs are most well studied for …

Our objective was to describe the pharmacokinetics of meropenem in the peritoneal fluid (PF)
of six patients with severe peritonitis and septic shock and to relate measured …