User profiles for Rakesh K. Tyagi

Rakesh K Tyagi

Professor
Verified email at mail.jnu.ac.in
Cited by 2446

Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells

RK Tyagi, Y Lavrovsky, SC Ahn, CS Song… - Molecular …, 2000 - academic.oup.com
An expression construct containing the cDNA encoding a modified aequorea green
fluorescent protein (GFP) ligated to the 5′-end of the rat androgen receptor (AR) cDNA (GFP-AR) …

Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: an overview

S Kumar, M Saradhi, NK Chaturvedi… - Molecular and cellular …, 2006 - Elsevier
Subcellular compartmentalization and dynamic movements of steroid receptors are major
steps in executing their transcription regulatory function. Though significant progress has been …

Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions

S Kumar, R Vijayan, AK Dash, S Gourinath… - Biochimica et Biophysica …, 2021 - Elsevier
Mitosis is a cellular process that produces two identical progenies. Genome-wide transcription
is believed to be silenced during mitosis. However, some transcription factors have been …

Simultaneous extraction of cellular lipids and water‐soluble metabolites: evaluation by NMR spectroscopy

RK Tyagi, A Azrad, H Degani… - Magnetic resonance in …, 1996 - Wiley Online Library
A method for simultaneous extraction of lipids and water‐soluble metabolites from a single
cell sample was developed and optimized for NMR spectroscopy. Intermediary metabolites in …

Androgen receptor: structural domains and functional dynamics after ligand‐receptor interaction

AK Roy, RK Tyagi, CS Song… - Annals of the New …, 2001 - Wiley Online Library
Androgens are C‐19 steroids secreted primarily from the testes and adrenals that play a
critical role in reproduction. Reproductive functions of androgens are mediated through …

Global footprints of organochlorine pesticides: a pan-global survey

…, H Dilnashin, H Birla, P Roy, RK Tyagi… - Environmental …, 2022 - Springer
Organochlorine pesticides (OCPs) are ubiquitous environmental contaminants widely used
all over the world. These chlorinated hydrocarbons are toxic and often cause detrimental …

An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts

…, M Sanghamitra, RK Tyagi… - Antioxidants & Redox …, 2006 - liebertpub.com
Cardiac myocytes, upon exposure to increasing doses of norepinephrine (NE), transit from
hypertrophic to apoptotic phenotype. Since reactive oxygen species (ROS) generation is …

[HTML][HTML] Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor

M Dagar, JP Singh, G Dagar, RK Tyagi… - Journal of Biological …, 2019 - ASBMB
The androgen receptor (AR) is often activated in prostate cancer patients undergoing
androgen-ablative therapy because of the activation of cellular pathways that stimulate the AR …

Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate

RK Tyagi, L Amazit, P Lescop, E Milgrom… - Molecular …, 1998 - academic.oup.com
Steroid hormone receptors are, in most cases, mainly nuclear proteins that undergo a
continuous nucleocytoplasmic shuttling. The mechanism of the nuclear export of these proteins …

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor

…, C Brimer-Cline, J Wu, EG Schuetz, RK Tyagi… - Drug metabolism and …, 2009 - ASPET
The pregnane X receptor (PXR) plays crucial roles in multiple physiological processes.
However, the signaling mechanisms responsible are not well defined; it is most likely that …