Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
…, DJ Hazuda, P Jones, O Kinzel, R Laufer… - Journal of medicinal …, 2008 - ACS Publications
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded
enzymes required for replication and therefore a rational target for chemotherapeutic …
enzymes required for replication and therefore a rational target for chemotherapeutic …
Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides
DJ Marsh, G Hollopeter, D Huszar, R Laufer… - Nature …, 1999 - nature.com
Mutations reducing the functional activity of leptin 1, 2, the leptin receptor 3, 4, α–melanocyte
stimulating hormone 5 (α–MSH) and the melanocortin–4 receptor 6 (Mc4r) all lead to …
stimulating hormone 5 (α–MSH) and the melanocortin–4 receptor 6 (Mc4r) all lead to …
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation
…, R Cortese, G Ciliberto, R Laufer… - Proceedings of the …, 1999 - National Acad Sciences
We show that an electric treatment in the form of high-frequency, low-voltage electric pulses
can increase more than 100-fold the production and secretion of a recombinant protein from …
can increase more than 100-fold the production and secretion of a recombinant protein from …
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
…, R Cortese, G Ciliberto, R Laufer - Proceedings of the …, 1997 - National Acad Sciences
Receptor subunits for the neurocytokine ciliary neurotrophic factor (CNTF) share sequence
similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight …
similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight …
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
…, V Knappertz, MR Hayden, R Laufer - Proceedings of the …, 2016 - National Acad Sciences
Laquinimod is an oral drug currently being evaluated for the treatment of relapsing, remitting,
and primary progressive multiple sclerosis and Huntington’s disease. Laquinimod exerts …
and primary progressive multiple sclerosis and Huntington’s disease. Laquinimod exerts …
4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic …
…, E Muraglia, M Rowley, OG Paz, R Laufer… - Journal of medicinal …, 2006 - ACS Publications
The dihydroxypyrimidine carboxamide 4a was discovered as a potent and selective HIV
integrase strand transfer inhibitor. The optimization of physicochemical properties, …
integrase strand transfer inhibitor. The optimization of physicochemical properties, …
Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Pridopidine has demonstrated improvement in Huntington Disease (HD) motor symptoms
as measured by secondary endpoints in clinical trials. Originally described as a dopamine …
as measured by secondary endpoints in clinical trials. Originally described as a dopamine …
Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors
Human immunodeficiency virus type-1 (HIV-1) integrase, one of the three constitutive viral
enzymes required for replication, is a rational target for chemotherapeutic intervention in the …
enzymes required for replication, is a rational target for chemotherapeutic intervention in the …
Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant
E Muraglia, OD Kinzel, R Laufer, MD Miller… - Bioorganic & medicinal …, 2006 - Elsevier
A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside
reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N …
reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N …
Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase
…, G Migliaccio, R De Francesco, R Laufer… - Journal of medicinal …, 2005 - ACS Publications
Infections caused by hepatitis C virus (HCV) are a significant world health problem for which
novel therapies are in urgent demand. Compounds that block replication of subgenomic …
novel therapies are in urgent demand. Compounds that block replication of subgenomic …