Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes
J Tang, Y Cao, RL Rose, AA Brimfield, D Dai… - Drug metabolism and …, 2001 - ASPET
One of the factors determining the toxicity of chlorpyrifos (CPS), an organophosphorus (OP)
insecticide, is its biotransformation. CPS can be activated by cytochrome P450 (CYP) …
insecticide, is its biotransformation. CPS can be activated by cytochrome P450 (CYP) …
Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.
…, R Linderman, E Hodgson, RL Rose - Environmental health …, 2000 - ehp.niehs.nih.gov
… Coleman S, Liu S, Linderman R, Hodgson E, Rose RL. In vitro metabolism of alachlor by
human liver microsomes and human cytochrome P450 isoforms. Chem Biol Interact 122:27–39 (…
human liver microsomes and human cytochrome P450 isoforms. Chem Biol Interact 122:27–39 (…
Cytochrome P450-associated insecticide resistance and the development of biochemical diagnostic assays in Heliothis virescens
RL RosE, L Barbhaiya, RM Roe, GC Rock… - Pesticide Biochemistry …, 1995 - Elsevier
The metabolic enzymes of a multiresistant (ie, carbamate, organophosphate, pyrethroid)
population of tobacco budworm, Heliothis virescens (F.), were compared with those of a …
population of tobacco budworm, Heliothis virescens (F.), were compared with those of a …
Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes
…, Y Cao, N Cherrington, E Hodgson, RL Rose - Chemico-Biological …, 2006 - Elsevier
Recent studies have demonstrated the potential of pesticides to either inhibit or induce
xenobiotic metabolizing enzymes in humans. Exposure of human hepatocytes to doses of fipronil …
xenobiotic metabolizing enzymes in humans. Exposure of human hepatocytes to doses of fipronil …
Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals
KA Usmani, RL Rose, E Hodgson - Drug Metabolism and Disposition, 2003 - ASPET
Cytochrome P450 (P450) enzymes are major catalysts involved in the metabolism of xenobiotics
and endogenous substrates such as testosterone (TST). Major TST metabolites formed …
and endogenous substrates such as testosterone (TST). Major TST metabolites formed …
The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals
E Hodgson, RL Rose - Pharmacology & therapeutics, 2007 - Elsevier
Cytochrome P450 (CYP) 2B6 (CYP2B6) is a human CYP isoform found in variable amounts
in the liver and other organs. It is known to be inducible and polymorphic and has a wide …
in the liver and other organs. It is known to be inducible and polymorphic and has a wide …
In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos
J Tang, Y Cao, RL Rose, E Hodgson - Chemico-biological interactions, 2002 - Elsevier
Carbaryl is a widely used anticholinesterase carbamate insecticide. Although previous
studies have demonstrated that carbaryl can be metabolized by cytochrome P450 (CYP), the …
studies have demonstrated that carbaryl can be metabolized by cytochrome P450 (CYP), the …
In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam
J Tang, KA Usmani, E Hodgson, RL Rose - Chemico-biological interactions, 2004 - Elsevier
Fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile)
is a highly active, broad spectrum insecticide from the phenyl pyrazole …
is a highly active, broad spectrum insecticide from the phenyl pyrazole …
Tobacco budworm P-glycoprotein: biochemical characterization and its involvement in pesticide resistance
…, RL Fine, JJ Corcoran, HM Ayad, RL Rose… - … et Biophysica Acta (BBA …, 1996 - Elsevier
Since pesticides have been shown to interact with P-glycoprotein (P-gp), the purpose of this
study was to examine the possible role of P-gp in pesticide resistance in the tobacco …
study was to examine the possible role of P-gp in pesticide resistance in the tobacco …
In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes
TM Cho, RL Rose, E Hodgson - Drug metabolism and disposition, 2006 - ASPET
The Polycyclic Aromatic Hydrocarbon Naphthalene Is An Environmental Pollutant, A Component
Of Jet Fuel, And, Since 2000, Has Been Reclassified As A Potential Human Carcinogen…
Of Jet Fuel, And, Since 2000, Has Been Reclassified As A Potential Human Carcinogen…