Although vitamin E has been known as an essential nutrient for reproduction since 1922, we
are far from understanding the mechanisms of its physiological functions. Vitamin E is the …

BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re-…

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems still …

The family of glutathione peroxidases comprises four distinct mammalian selenoproteins.
The classical enzyme (cGPx) is ubiquitously distributed. According to animal, cell culture and …

Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-κB/IκB) complex leading to its
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …

Vitamin E is indispensible for reproduction in female rats. In humans, vitamin E deficiency
primarily causes neurologic dysfunctions, but the underlying molecular mechanisms are …

Several decades after the discovery of selenium as an essential trace element in vertebrates
approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the …

Vitamin E is the last of all vitamins whose essentiality is not yet understood. Its widely accepted
role as a lipophilic antioxidant has been questioned, since proof of its in vivo relevance …

Abstract Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in
mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), …

The gastrointestinal glutathione peroxidase (GI-GPx, GPx2) is a selenoprotein that was
suggested to act as barrier against hydroperoxide absorption but has also been implicated in the …