Evolution in the structure and function of aspartic proteases

J Tang, RNS Wong - Journal of cellular biochemistry, 1987 - Wiley Online Library
Aspartic proteases (EC3. 4.23) are a group of proteolytic enzymes of the pepsin family that
share the same catalytic apparatus and usually function in acid solutions. This latter aspect …

Angiogenesis: from plants to blood vessels

…, JC Yeh, KW Leung, PYK Yue, RNS Wong - Trends in …, 2006 - cell.com
Angiogenesis is a major pathological component of diseases such as cancer and coronary
heart disease. Although major advances have been made and encouraging clinical results …

Modulating angiogenesis: the yin and the yang in ginseng

…, P Koolwijk, HW Leung, HW Yeung, RNS Wong… - Circulation, 2004 - Am Heart Assoc
Background— Ginseng is a commonly used nutraceutical. Intriguingly, existing literature
reports both wound-healing and antitumor effects of ginseng extract through opposing activities …

The angiosuppressive effects of 20 (R)-ginsenoside Rg3

PYK Yue, DYL Wong, PK Wu, PY Leung… - Biochemical …, 2006 - Elsevier
Aberrant angiogenesis is an essential step for the progression of solid tumors. Thus anti-angiogenic
therapy is one of the most promising approaches to control tumor growth. In this …

A simplified method for quantifying cell migration/wound healing in 96-well plates

…, EPY Leung, NK Mak, RNS Wong - Journal of …, 2010 - journals.sagepub.com
Cell migration plays a key role in both normal physiological and pathological conditions.
The study of cell migration and its underlying mechanisms is of great significance in various …

[HTML][HTML] Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β …

KW Leung, YL Pon, RNS Wong, AST Wong - Journal of Biological …, 2006 - ASBMB
Ginsenoside-Rg1, the most prevalent active constituent of ginseng, is a potent proangiogenic
factor of vascular endothelial cells. This suggests that Rg1 may be a new modality for …

[HTML][HTML] Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells

…, YK Cheng, NK Mak, KKC Chan, TPD Fan, RNS Wong - FEBS letters, 2006 - Elsevier
We here provide definitive evidence that ginsenoside-Rg1, the pharmacologically active
component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined …

In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3

T Qian, Z Cai, RNS Wong, NK Mak, ZH Jiang - Journal of Chromatography …, 2005 - Elsevier
Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg 3 ,
was studied for better understanding its pharmacokinetics in rat. LC–MS was used to …

The anti-angiogenic effect of sinomenine

TW Kok, PYK Yue, NK Mak, TPD Fan, L Liu, RNS Wong - Angiogenesis, 2005 - Springer
Sinomenine is an alkaloid extracted from the Chinese medicinal plant, Sinomenium acutum,
which has been utilized to treat rheumatoid arthritis (RA) in China for over 2000 years. …

Differentiation of Lycium barbarum from its related Lycium species using random amplified polymorphic DNA

…, HW Leung, HW Yeung, RNS Wong - Planta medica, 2001 - thieme-connect.com
The RAPD (random amplified polymorphic DNA) technique was applied for the first time to
distinguish Lycium barbarum from other closely related species of the same genus. In this …