Evolution in the structure and function of aspartic proteases
J Tang, RNS Wong - Journal of cellular biochemistry, 1987 - Wiley Online Library
Aspartic proteases (EC3. 4.23) are a group of proteolytic enzymes of the pepsin family that
share the same catalytic apparatus and usually function in acid solutions. This latter aspect …
share the same catalytic apparatus and usually function in acid solutions. This latter aspect …
Angiogenesis: from plants to blood vessels
…, JC Yeh, KW Leung, PYK Yue, RNS Wong - Trends in …, 2006 - cell.com
Angiogenesis is a major pathological component of diseases such as cancer and coronary
heart disease. Although major advances have been made and encouraging clinical results …
heart disease. Although major advances have been made and encouraging clinical results …
Modulating angiogenesis: the yin and the yang in ginseng
…, P Koolwijk, HW Leung, HW Yeung, RNS Wong… - Circulation, 2004 - Am Heart Assoc
Background— Ginseng is a commonly used nutraceutical. Intriguingly, existing literature
reports both wound-healing and antitumor effects of ginseng extract through opposing activities …
reports both wound-healing and antitumor effects of ginseng extract through opposing activities …
The angiosuppressive effects of 20 (R)-ginsenoside Rg3
Aberrant angiogenesis is an essential step for the progression of solid tumors. Thus anti-angiogenic
therapy is one of the most promising approaches to control tumor growth. In this …
therapy is one of the most promising approaches to control tumor growth. In this …
A simplified method for quantifying cell migration/wound healing in 96-well plates
…, EPY Leung, NK Mak, RNS Wong - Journal of …, 2010 - journals.sagepub.com
Cell migration plays a key role in both normal physiological and pathological conditions.
The study of cell migration and its underlying mechanisms is of great significance in various …
The study of cell migration and its underlying mechanisms is of great significance in various …
[HTML][HTML] Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β …
KW Leung, YL Pon, RNS Wong, AST Wong - Journal of Biological …, 2006 - ASBMB
Ginsenoside-Rg1, the most prevalent active constituent of ginseng, is a potent proangiogenic
factor of vascular endothelial cells. This suggests that Rg1 may be a new modality for …
factor of vascular endothelial cells. This suggests that Rg1 may be a new modality for …
[HTML][HTML] Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells
We here provide definitive evidence that ginsenoside-Rg1, the pharmacologically active
component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined …
component of ginseng, is a functional ligand of the glucocorticoid receptor (GR) as determined …
In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3
T Qian, Z Cai, RNS Wong, NK Mak, ZH Jiang - Journal of Chromatography …, 2005 - Elsevier
Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg 3 ,
was studied for better understanding its pharmacokinetics in rat. LC–MS was used to …
was studied for better understanding its pharmacokinetics in rat. LC–MS was used to …
The anti-angiogenic effect of sinomenine
Sinomenine is an alkaloid extracted from the Chinese medicinal plant, Sinomenium acutum,
which has been utilized to treat rheumatoid arthritis (RA) in China for over 2000 years. …
which has been utilized to treat rheumatoid arthritis (RA) in China for over 2000 years. …
Differentiation of Lycium barbarum from its related Lycium species using random amplified polymorphic DNA
…, HW Leung, HW Yeung, RNS Wong - Planta medica, 2001 - thieme-connect.com
The RAPD (random amplified polymorphic DNA) technique was applied for the first time to
distinguish Lycium barbarum from other closely related species of the same genus. In this …
distinguish Lycium barbarum from other closely related species of the same genus. In this …