The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic
elimination occurs primarily by hepatic metabolism. When administered as a lozenge for oral …

The diastereoisomers of dioxindolyl-L-alanine are obtained in a 1: 1 ratio by air oxidation of
oxindolyl-L-alanine. Preparative separation of the diastereoisomers is achieved by reverse-…

The synthetic opioid alfentanil (ALF) undergoes extensive metabolism via two major pathways:
piperidine nitrogen dealkylation to noralfentanil (NA) and amide nitrogen dealkylation to …

… dissertation (1990) of Rita B. … The catalytic effect of DMAP may depend (a) on its
function as a general base in facilitating the addition of methanol to the carbonyl group of …

… Rita B. Labroo …

The short-acting synthetic opioid alfentanil undergoes extensive biotransformation to
several metabolites. A gas chromatographic—mass spectrometric assay, using selected-ion …

This report describes a simple gas chromatographic—mass spectrometric (GC—MS) assay
for the simultaneous analysis of alfentanil and its major metabolite, noralfentanil, in human …

Nefopam (NEF) is a potent analgesic compound administered as a racemic mixture. Previous
in vitro and in vivo studies with nefopam enantiomers have shown that (+)nefopam [(+)NEF…

This paper describes a chemoenzymatic procedure for the synthesis of (R)-and (S)-glycidaldehyde
diethyl acetal [2-(diethoxymethyl) oxirane](4 and 5). 2-Acetoxy-3-chloropropanal …

Influence of stiripentol on cytochrome P450â•’mediated metabolic pathways in humans: In
vitro and in vivo comparison and ca Page 1 Influence of stirkxntol on cytochrome I?4510 -…