Steroidogenesis in the skin: implications for local immune functions
…, A Postlethwaite, CC Zouboulis, RC Tuckey - The Journal of steroid …, 2013 - Elsevier
The skin has developed a hierarchy of systems that encompasses the skin immune and local
steroidogenic activities in order to protect the body against the external environment and …
steroidogenic activities in order to protect the body against the external environment and …
Progesterone synthesis by the human placenta
RC Tuckey - Placenta, 2005 - Elsevier
One of the essential roles of the human placenta is to produce the steroid hormone
progesterone, which is required for the maintenance of pregnancy. The rate-determining step of …
progesterone, which is required for the maintenance of pregnancy. The rate-determining step of …
[HTML][HTML] In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1
…, CR Yates, A Postlethwaite, W Li, RC Tuckey - The FASEB …, 2012 - ncbi.nlm.nih.gov
We define previously unrecognized in vivo pathways of vitamin D 3 (D3) metabolism generating
novel D3-hydroxyderivatives different from 25-hydroxyvitamin D 3 [25 (OH) D3] and 1, …
novel D3-hydroxyderivatives different from 25-hydroxyvitamin D 3 [25 (OH) D3] and 1, …
Differential expression of HPA axis homolog in the skin
A Slominski, J Wortsman, RC Tuckey, R Paus - Molecular and cellular …, 2007 - Elsevier
Human skin expresses elements of the hypothalamo-pituitary-adrenal (HPA) axis including
pro-opiomelanocortin (POMC), corticotropin releasing hormone (CRH), the CRH receptor-1 (…
pro-opiomelanocortin (POMC), corticotropin releasing hormone (CRH), the CRH receptor-1 (…
[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-hydroxyvitamin
D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3]. Chinese …
D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3]. Chinese …
Novel activities of CYP11A1 and their potential physiological significance
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol and …
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol and …
A novel pathway for sequential transformation of 7‐dehydrocholesterol and expression of the P450scc system in mammalian skin
…, J Marcos, C Dunbar, R C. Tuckey - European Journal of …, 2004 - Wiley Online Library
Following up on our previous findings that the skin possesses steroidogenic activity from
progesterone, we now show widespread cutaneous expression of the full cytochrome P450 side…
progesterone, we now show widespread cutaneous expression of the full cytochrome P450 side…
Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation
…, JC Dowdy, RM Sayre, RC Tuckey… - American Journal …, 2011 - journals.physiology.org
The hypothalamic-pituitary-adrenal (HPA) axis maintains basal and stress-related homeostasis
in vertebrates. Skin expresses all elements of the HPA axis including corticotropin-…
in vertebrates. Skin expresses all elements of the HPA axis including corticotropin-…
[HTML][HTML] Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland
…, A Postlethwaite, EW Tieu, EKY Tang, RC Tuckey - Scientific reports, 2015 - nature.com
To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC)
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …
The serum vitamin D metabolome: What we know and what is still to discover
RC Tuckey, CYS Cheng, AT Slominski - The Journal of steroid biochemistry …, 2019 - Elsevier
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most hormonally …
phototransformation in the skin, is a prohormone important in human health. The most hormonally …