Drugs which inhibit prostaglandin biosynthesis

RJ Flower - Pharmacological Reviews, 1974 - ASPET
Three classes of compounds inhibit prostaglandin synthetase. The first group consists of the
substrate analogues. The specificity of these analogues is unknown but many possess good …

Annexin‐A1: a pivotal regulator of the innate and adaptive immune systems

…, M Perretti, RJ Flower - British journal of …, 2008 - Wiley Online Library
The glucocorticoids are the most potent anti‐inflammatory drugs that we possess and are
effective in a wide variety of diseases. Although their action is known to involve receptor …

The development of COX2 inhibitors

RJ Flower - Nature Reviews Drug Discovery, 2003 - nature.com
Aspirin, arguably the world's favourite drug, has been around since the late nineteenth century,
but it wasn't until the late 1970s that its ability to inhibit prostaglandin production by the …

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

…, C Thiemermann, RJ Flower… - Proceedings of the …, 1993 - National Acad Sciences
Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1)
is present in cells under physiological conditions, whereas COX-2 is induced by some …

The electronic aggregometer: a novel device for assessing platelet behavior in blood

DC Cardinal, RJ Flower - Journal of pharmacological methods, 1980 - Elsevier
A novel device for measuring platelet aggregation has been devised. The technique, which
depends upon changes in electrical impedence caused by platelet accretion onto electrodes…

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

GJ Blackwell, R Carnuccio, MD Rosa, RJ Flower… - Nature, 1980 - nature.com
Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing
arachidonic acid release from phos-pholipids rather than inhibiting the cyclooxygenase 1–16 . …

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

…, R Yang, D Cooper, NA Petasis, RJ Flower… - Nature, 2009 - nature.com
A growing body of evidence indicates that resolution of acute inflammation is an active
process 1 , 2 . Resolvins are a new family of lipid mediators enzymatically generated within …

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

RJ Gryglewski, S Bunting, S Moncada, RJ Flower… - Prostaglandins, 1976 - Elsevier
Prostaglandin (PG) endoperoxides (PGG 2 and PGH 2 ) contract arterial smooth muscle and
cause platelet aggregation. Microsomes from pig aorta, pig mesenteric arteries, rabbit aorta …

Aberrant inflammation and resistance to glucocorticoids in Annexin 1−/− Mouse

…, JF Morris, JC Buckingham, RJ Flower - The FASEB …, 2003 - Wiley Online Library
The 37‐kDa protein annexin 1 (Anx‐1; lipocortin 1) has been implicated in the regulation of
phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of …

Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation

…, JC Buckingham, M Perretti, RJ Flower - The Journal of …, 2010 - journals.aai.org
The human formyl-peptide receptor (FPR)-2 is a G protein-coupled receptor that transduces
signals from lipoxin A 4, annexin A1, and serum amyloid A (SAA) to regulate inflammation. In …