Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted to the active thrombin
inhibitor, dabigatran (DAB), by serine esterases. The aims of the present study were to …

Introduction: Mammalian carboxylesterase enzymes are a highly conserved metabolic pathway
involved in the metabolism of endogenous and exogenous compounds including many …

Carboxylesterases are important in the metabolism of cocaine, catalyzing the hydrolysis of
cocaine to its two major metabolites, benzoylecgonine and ecgonine methyl ester. In the …

• We studied the steady-state pharmacokinetics of bupropion hydrochloride, a unicyclic
aminoketone antidepressant, in depressed patients. The metabolites hydroxybupropion (HB), …

The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the
erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were …

Background and Objective Human carboxylesterase-1 (CES1) and human carboxylesterase-2
(CES2) play an important role in metabolizing many medications. Alcohol is a known …

Study Objectives. To determine the effects of grapefruit juice on the pharmacokinetics of oral
digoxin, a P‐glycoprotein substrate not metabolized by cytochrome P450 3A4, in healthy …

Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted by esterases to
dabigatran (DAB), a direct inhibitor of thrombin. To elucidate the esterase-mediated metabolic …

Bupropion (BUP) is a new, monocyclic, second-generation antide-pressant with efficacy
comparable with that of the tricyclics but possessing a more favorable side-effect profile. …

Caffeine is a mild stimulant with significant potential for abuse, being consumed in larger
doses with the widespread availability of energy drinks and by novel routes of administration …