Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active O‐desmethyl metabolite
…, K Moloney, RL Rudolph, SF Sisenwine… - The Journal of …, 1992 - Wiley Online Library
Venlafaxine is a structurally novel, nontricyclic compound that is being evaluated for the
treatment of various depressive disorders. A randomized three‐period crossover study was …
treatment of various depressive disorders. A randomized three‐period crossover study was …
Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man
…, GEM Husbands, JA Scatina, SF Sisenwine - Xenobiotica, 1993 - Taylor & Francis
… A comparable cyclization process has been seen with a similar compound, ciramadol (Sisenwine
et al. 1982). The mechanism by which VIII is formed has not been defined, but might …
et al. 1982). The mechanism by which VIII is formed has not been defined, but might …
Pharmacokinetics of venlafaxine and O-desmethylvenlafaxine in laboratory animals
SR Howell, DR Hicks, JA Scatina, SF Sisenwine - Xenobiotica, 1994 - Taylor & Francis
… A,, and SISENWINE, SF, 1992, The disposition of venlafaxine enantiomers in dogs, rats,
and humans receiving venlafaxine. Chirality, 4, 84-90. YARDLEY, JP,HCSBANDS, G . …
and humans receiving venlafaxine. Chirality, 4, 84-90. YARDLEY, JP,HCSBANDS, G . …
Clinical pharmacokinetics of lorazepam
…, RI Shader, SF Sisenwine… - Clinical …, 1976 - Wiley Online Library
Eight healthy male subjects received single 2‐mg oral doses of lorazepam containing 24 uLCi
Img of 2‐ 14 C‐lorazepam. Multiple venous blood samples were drawn during the .first 96 …
Img of 2‐ 14 C‐lorazepam. Multiple venous blood samples were drawn during the .first 96 …
The disposition of venlafaxine enantiomers in dogs, rats, and humans receiving venlafaxine
C Paul Wang, SR Howell, J Scatina, SF Sisenwine - Chirality, 1992 - Wiley Online Library
A stereospecific high‐performance liquid chromatographic (HPLC) method was developed
for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and …
for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and …
The Application of In Vitro Models of Drug Metabolism and Toxicity in Drug Discovery and Drug Development
SE Ball, JA Scatina, SF Sisenwine… - Drug and chemical …, 1995 - Taylor & Francis
In vitro models are being used increasingly during all phases of the drug development process
in concert with the more traditional in vivo toxicological and pharmacokinetic evaluations. …
in concert with the more traditional in vivo toxicological and pharmacokinetic evaluations. …
Species-related differences in the stereoselective glucuronidation of oxazepam.
SF Sisenwine, CO Tio, FV Hadley, AL Liu… - Drug Metabolism and …, 1982 - ASPET
The concentrations of (R)-(-)- and (S)-(+)-oxazepam glucuronides in plasma and urine of
several species have been measured. The relative amounts of these diastereoisomers vary …
several species have been measured. The relative amounts of these diastereoisomers vary …
High performance liquid chromatographic isolation and spectroscopic characterization of three major metabolites from the plasma of rats receiving rapamycin …
…, KW Chan, J Scatina, SF Sisenwine - Journal of Liquid …, 1995 - Taylor & Francis
Three major metabolites of rapamycin (M2, M3, and M5) were isolated from pooled plasma
of orally dosed rats. Metabolites were extracted from the plasma with ethyl acetate/methanol …
of orally dosed rats. Metabolites were extracted from the plasma with ethyl acetate/methanol …
[PDF][PDF] Plasma concentrations and urinary excretion of isosorbide dinitrate and its metabolites in the dog
SF SISENWINE, HW RUELIUS - Journal of Pharmacology and …, 1971 - Citeseer
ABSTRACT SISENWINE, SF Htxs W. Ruzuns: Plasma concentrations and urinary excretion
of isosorbide dinitrate and its metabolites in the dog. J. Pharmacol. Exp. Ther. 176: 296-301,
of isosorbide dinitrate and its metabolites in the dog. J. Pharmacol. Exp. Ther. 176: 296-301,
High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two rapamycin degradation products
…, RA Schiksnis, J Scatina, SF Sisenwine - Journal of liquid …, 1994 - Taylor & Francis
A high performance liquid chromatographic method has been developed for the isolation of
two degradation products of rapamycin which is currently under development as an …
two degradation products of rapamycin which is currently under development as an …