User profiles for S. John Gatley
 | Samuel GatleyProfessor of Pharmaceutical Sciences, Northeastern University Verified email at neu.edu Cited by 23641 |
Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
…, R Hitzemann, B Bendriem, SJ Gatley… - Journal of Cerebral …, 1990 - journals.sagepub.com
A graphical method of analysis applicable to ligands that bind reversibly to receptors or
enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for …
enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for …
Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
OBJECTIVE: Methamphetamine is a popular and highly addictive drug of abuse that has raised
concerns because it has been shown in laboratory animals to be neurotoxic to dopamine …
concerns because it has been shown in laboratory animals to be neurotoxic to dopamine …
Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2receptors
Increases in dopamine concentration in limbic brain regions have been postulated to underlie
the reinforcing effects of psychostimulant drugs in laboratory animals. However, neither …
the reinforcing effects of psychostimulant drugs in laboratory animals. However, neither …
Mechanism of action of methylphenidate: insights from PET imaging studies
Methylphenidate (MPH) is the most commonly prescribed drug for the treatment of Attention-Deficit/Hyperactivity
Disorder (ADHD). We have used Positron Emission Tomography (PET) …
Disorder (ADHD). We have used Positron Emission Tomography (PET) …
Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
OBJECTIVE: Despite the well-documented loss of brain dopamine activity with age, little is
known about its functional consequences in healthy individuals. This study investigates the …
known about its functional consequences in healthy individuals. This study investigates the …
[PDF][PDF] Dopamine transporters decrease with age
(26). Carbon-i id-threo-methylphenidate binding is inhibited by drugs that bind to the
dopamine transporter, but not by drugs that inhibit the norepinephrine and the serotonin …
dopamine transporter, but not by drugs that inhibit the norepinephrine and the serotonin …
Brain dopamine is associated with eating behaviors in humans
Objective Eating behavior in humans is influenced by variables other than just hunger‐satiety
including cognitive restraint, emotional distress, and sensitivity to food stimuli. We …
including cognitive restraint, emotional distress, and sensitivity to food stimuli. We …
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
SJ Gatley, AN Gifford, ND Volkow, R Lan… - European journal of …, 1996 - Elsevier
We have investigated the binding of 123 I-labeled N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
(AM251), an analog of the …
(AM251), an analog of the …
Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers
OBJECTIVE: Methamphetamine has raised concerns because it may be neurotoxic to the
human brain. Although prior work has focused primarily on the effects of methamphetamine on …
human brain. Although prior work has focused primarily on the effects of methamphetamine on …
[PDF][PDF] PET evaluation of the dopamine system of the human brain
ND Volkow, JS Fowler, SJ Gatley, J Logan… - Journal of Nuclear …, 1996 - Soc Nuclear Med
Dopamine plays a pivotal role in the regulation and control of movement, motivation and
cognition. It also is closely linked to reward, reinforcement and addiction. Abnormalities in brain …
cognition. It also is closely linked to reward, reinforcement and addiction. Abnormalities in brain …