Vascular actions of 20-HETE
20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits
a myriad of biological effects in the vascular system. This review discusses the current …
a myriad of biological effects in the vascular system. This review discusses the current …
[PDF][PDF] Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development
…, HH Willcockson, WP Dunworth, SL Hoopes… - Developmental cell, 2014 - cell.com
Atypical 7-transmembrane receptors, often called decoy receptors, act promiscuously as
molecular sinks to regulate ligand bioavailability and consequently temper the signaling of …
molecular sinks to regulate ligand bioavailability and consequently temper the signaling of …
[HTML][HTML] Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia
…, JA Bradbury, LM DeGraff, SL Hoopes… - Journal of biological …, 2018 - ASBMB
Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have …
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have …
Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II
Aims Cardiac remodelling is one of the key pathological changes that occur with
cardiovascular disease. Previous studies have demonstrated the beneficial effects of CYP2J2 …
cardiovascular disease. Previous studies have demonstrated the beneficial effects of CYP2J2 …
[HTML][HTML] The role of cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids in metabolic diseases
X Xu, R Li, G Chen, SL Hoopes, DC Zeldin… - Advances in nutrition, 2016 - Elsevier
Metabolic diseases are associated with an increased risk of developing cardiovascular
disease. The features comprising metabolic diseases include obesity, insulin resistance, …
disease. The features comprising metabolic diseases include obesity, insulin resistance, …
[HTML][HTML] Vascular characterization of mice with endothelial expression of cytochrome P450 4F2
J Cheng, ML Edin, SL Hoopes, H Li… - The FASEB …, 2014 - ncbi.nlm.nih.gov
Cytochrome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic
acid (20-HETE). Although CYP4A-derived 20-HETE is known to have …
acid (20-HETE). Although CYP4A-derived 20-HETE is known to have …
[HTML][HTML] Characteristics of Multi-Organ Lymphangiectasia Resulting from Temporal Deletion of Calcitonin Receptor-Like Receptor in Adult Mice
SL Hoopes, HH Willcockson, KM Caron - 2012 - journals.plos.org
Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl)
and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells …
and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells …
[HTML][HTML] sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae
…, A Gruzdev, J Cheng, SL Hoopes… - The Journal of …, 2021 - Am Soc Clin Investig
Epoxyeicosatrienoic acids (EETs) have potent antiinflammatory properties. Hydrolysis of
EETs by soluble epoxide hydrolase/ epoxide hydrolase 2 (sEH/EPHX2) to less active diols …
EETs by soluble epoxide hydrolase/ epoxide hydrolase 2 (sEH/EPHX2) to less active diols …
Adrenomedullin function in vascular endothelial cells: insights from genetic mouse models
NO Karpinich, SL Hoopes, DO Kechele… - Current hypertension …, 2011 - ingentaconnect.com
Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes
ranging from pregnancy and embryonic development to tumor progression. This review …
ranging from pregnancy and embryonic development to tumor progression. This review …
[HTML][HTML] Purine biosynthesis in archaea: variations on a theme
AM Brown, SL Hoopes, RH White, CA Sarisky - Biology direct, 2011 - Springer
Background The ability to perform de novo biosynthesis of purines is present in organisms
in all three domains of life, reflecting the essentiality of these molecules to life. Although the …
in all three domains of life, reflecting the essentiality of these molecules to life. Although the …