Objective— Clinical studies suggest that platelet P2Y 12 inhibitors reduce mortality from
sepsis, although the underlying mechanisms have not been clearly defined in vivo. We …

Metformin is a common co‐medication for many diseases and the victim of clinical drug‐drug
interactions ( DDI s) perpetrated by cimetidine, trimethoprim and pyrimethamine, resulting …

Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin
exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted …

A previous attempt to accurately quantify the increased simvastatin acid exposure due to
drug-drug interaction (DDI) with coadministered telithromycin, using a mechanistic static model, …

Background: In the PLATO study, ticagrelor was unexpectedly associated with fewer deaths
following pulmonary infections and sepsis. The risk of myocardial infarction or stroke is …

Introduction In the PLATO study, the novel platelet P2Y 12 inhibitor ticagrelor was unexpectedly
associated with fewer deaths following pulmonary infections and sepsis than clopidogrel…

… Titres were low (neat or 1 in 2) at this time and decreased in one animal so that antibodies
were not detectable in samples obtained on the day of calving or 9 days beforehand. …

62 pyrrolizidine alkaloids and derivatives have been screened for acute and chronic hepato-
and pneumotoxicity by the single dose method previously described. This procedure is …

… to obtain sufficient cell numbers weight of nylon wool (Outteridge et al 198 results of two such
… Represe t Represe nts a popula nts a popula tion of eight tion of four I pooled sam pooled …