User profiles for Sara K. Quinney
Sara QuinneyProfessor of OB/GYN, Indiana University School of Medicine Verified email at iupui.edu Cited by 2662 |
Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia
…, AS Lehmann, AR Topletz, SK Quinney… - Pediatric blood & …, 2011 - Wiley Online Library
Background This study evaluates the relationship between cytochrome P450 (CYP) 3A5
genotype and vincristine‐induced peripheral neuropathy (VIPN) in children with precursor B …
genotype and vincristine‐induced peripheral neuropathy (VIPN) in children with precursor B …
Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
SK Quinney, SP Sanghani, WI Davis, TD Hurley… - … of Pharmacology and …, 2005 - ASPET
Capecitabine is an oral prodrug of 5-fluorouracil that is indicated for the treatment of breast
and colorectal cancers. A three-step in vivo-targeted activation process requiring …
and colorectal cancers. A three-step in vivo-targeted activation process requiring …
Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis
SP Sanghani, SK Quinney, TB Fredenburg, Z Sun… - Clinical Cancer …, 2003 - AACR
Purpose: The purpose is to develop new analytical methods to study the expression profile
of CPT-11 carboxylesterases and topoisomerase I in colon tumor samples and understand …
of CPT-11 carboxylesterases and topoisomerase I in colon tumor samples and understand …
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino) …
SP Sanghani, SK Quinney, TB Fredenburg… - Drug Metabolism and …, 2004 - ASPET
Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more
soluble acid, alcohol, and amine products. They belong to a multigene family with about 50% …
soluble acid, alcohol, and amine products. They belong to a multigene family with about 50% …
[HTML][HTML] Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions
Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we
combined a literature discovery approach with analysis of a large electronic medical record …
combined a literature discovery approach with analysis of a large electronic medical record …
Predicting the glomerular filtration rate in bariatric surgery patients
…, M Inman, SG Mattar, Z Shihabi, SK Quinney - American journal of …, 2014 - karger.com
Background/Aims: Identifying the best method to estimate the glomerular filtration rate (GFR)
in bariatric surgery patients has important implications for the clinical care of obese patients …
in bariatric surgery patients has important implications for the clinical care of obese patients …
Short-term tocolytics for preterm delivery–current perspectives
…, T Benjamin, R Sawyer, SK Quinney - International journal of …, 2014 - Taylor & Francis
Administration of short-term tocolytic agents can prolong pregnancy for women in preterm
labor. Prolonging pregnancy has many benefits because it allows for other proven …
labor. Prolonging pregnancy has many benefits because it allows for other proven …
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite
X Zhang, SK Quinney, JC Gorski, DR Jones… - Drug Metabolism and …, 2009 - ASPET
Prediction of the extent and time course of drug-drug interactions (DDIs) between the
mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is …
mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is …
Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin
SK Quinney, X Zhang, A Lucksiri, JC Gorski, L Li… - Drug metabolism and …, 2010 - ASPET
The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors
of CYP3A is complicated when the inhibitor itself is metabolized by CYP3Aas in the case of …
of CYP3A is complicated when the inhibitor itself is metabolized by CYP3Aas in the case of …
[HTML][HTML] Improving natural product research translation: From source to clinical trial
…, J Paul, K Pritchett-Corning, SK Quinney… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
While great interest in health effects of natural product (NP) including dietary supplements
and foods persists, promising preclinical NP research is not consistently translating into …
and foods persists, promising preclinical NP research is not consistently translating into …