Background Many studies have investigated the prognosis of nonalcoholic fatty liver disease
(NAFLD); however, most studies had a relatively short follow-up. To elucidate the long-term …

European studies have revealed that the ABCB11 c.1331T>C (V444A) polymorphism (rs2287622)
C-allele frequency is higher among patients with drug-induced cholestasis. Given the …

OBJECTIVE: Microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat
hippocampus elicited stress-like responses reflected by the release of adrenocorticotropic …

Objective: Hepatitis C virus (HCV) was identified in 1989. In 2020, three decades after HCV
identification, three researchers won the Nobel Prize in Physiology or Medicine for the …

It has been hypothesized that inflammatory mechanisms play a role in the pathogenesis of
several age-associated diseases. In addition, high plasma levels of inflammatory proteins …

Discussion OATP1B3 and NTCP can transport ICG in vitro. 5 An unrevealed deficiency of
NTCP in addition to the absence of OATP1B3 might have contributed to the lack of ICG uptake …

In the last decade, Brazilian economic policies have reduced the once 100% retirement
pensions for the middle class. This study also found that the middle class tended to keep …

… We thank Satsuki Ieda, Sachiko Suzuki, Tadayuki Sato, and Masayuki Tanaka for their
technical assistance. This work was supported in part by the Japan Agency for Medical Research …

Discussion OATP1B3 and NTCP can transport ICG in vitro. 5 An unrevealed deficiency of
NTCP in addition to the absence of OATP1B3 might have contributed to the lack of ICG uptake …

The age-associated decline of dopamine D 2 receptor (D 2 R) densities is one of the
notable features of aging in mammalian brains. The concept of a functional dopamine (DA) –…