[PDF][PDF] Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer's disease
…, A Koyanagi, S Furuya, M Gaudin-Guérif, S Goutal… - Cell metabolism, 2020 - cell.com
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
Carbon Dioxide Radical Anion by Photoinduced Equilibration between Formate Salts and [11C, 13C, 14C]CO2: Application to Carbon Isotope Radiolabeling
…, A Talbot, O Loreau, T D'Anfray, S Goutal… - Journal of the …, 2023 - ACS Publications
The need for carbon-labeled radiotracers is increasingly higher in drug discovery and
development (carbon-14, β – , t 1/2 = 5730 years) as well as in positron emission tomography (PET…
development (carbon-14, β – , t 1/2 = 5730 years) as well as in positron emission tomography (PET…
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?
L Breuil, S Marie, S Goutal, S Auvity… - Journal of Cerebral …, 2022 - journals.sagepub.com
Only partial deficiency/inhibition of P-glycoprotein (P-gp, ABCB1) function at the blood-brain
barrier (BBB) is likely to occur in pathophysiological situations or drug-drug interactions. …
barrier (BBB) is likely to occur in pathophysiological situations or drug-drug interactions. …
Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging
S Lavisse, S Goutal, C Wimberley, M Tonietto… - Parkinsonism & related …, 2021 - Elsevier
Introduction Increasing evidence suggests that neuroinflammation is active in Parkinson
disease (PD) and contributes to neurodegeneration. This process can be studied in vivo with …
disease (PD) and contributes to neurodegeneration. This process can be studied in vivo with …
Strategies to inhibit ABCB1-and ABCG2-mediated efflux transport of erlotinib at the blood–brain barrier: a PET study on nonhuman primates
N Tournier, S Goutal, S Auvity, A Traxl… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The tyrosine kinase inhibitor erlotinib poorly penetrates the blood–brain barrier (BBB)
because of efflux transport by P-glycoprotein (ABCB1) and breast cancer resistance protein (…
because of efflux transport by P-glycoprotein (ABCB1) and breast cancer resistance protein (…
Metabolism and quantification of [18F] DPA-714, a new TSPO positron emission tomography radioligand
MA Peyronneau, W Saba, S Goutal, A Damont… - Drug Metabolism and …, 2013 - ASPET
[ 18 F]DPA-714 [N,N-diethyl-2-(2-(4-(2[ 18 F]-fluoroethoxy)phenyl)5,7dimethylpyrazolo[1,5a]pyrimidin-3-yl)acetamide]
is a new radioligand currently used for imaging the 18-kDa …
is a new radioligand currently used for imaging the 18-kDa …
Physical blood-brain barrier disruption induced by focused ultrasound does not overcome the transporter-mediated efflux of erlotinib
S Goutal, M Gerstenmayer, S Auvity, F Caillé… - Journal of controlled …, 2018 - Elsevier
Overcoming the efflux mediated by ATP–binding cassette (ABC) transporters at the blood-brain
barrier (BBB) remains a challenge for the delivery of small molecule tyrosine kinase …
barrier (BBB) remains a challenge for the delivery of small molecule tyrosine kinase …
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 …
N Tournier, S Goutal, S Mairinger… - Journal of Cerebral …, 2021 - journals.sagepub.com
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict at the blood–brain
barrier (BBB) the brain distribution of the majority of currently known molecularly …
barrier (BBB) the brain distribution of the majority of currently known molecularly …
P-Glycoprotein (ABCB1) inhibits the influx and increases the efflux of 11C-metoclopramide across the blood–brain barrier: a PET study on nonhuman primates
PET imaging using radiolabeled avid substrates of the ATP-binding cassette (ABC) transporter
P-glycoprotein (ABCB1) has convincingly revealed the role of this major efflux transporter …
P-glycoprotein (ABCB1) has convincingly revealed the role of this major efflux transporter …
Imaging the impact of the P-glycoprotein (ABCB1) function on the brain kinetics of metoclopramide
G Pottier, S Marie, S Goutal, S Auvity… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The effects of metoclopramide on the central nervous system (CNS) in patients suggest
substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may …
substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may …