Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations
G Lee, S Dallas, M Hong, R Bendayan - Pharmacological reviews, 2001 - ASPET
Drug transport in the central nervous system is highly regulated not only by the blood-brain
and the blood-cerebrospinal fluid barriers but also in brain parenchyma. The novel …
and the blood-cerebrospinal fluid barriers but also in brain parenchyma. The novel …
Multidrug resistance-associated proteins: expression and function in the central nervous system
S Dallas, DS Miller, R Bendayan - Pharmacological reviews, 2006 - ASPET
Drug delivery to the brain is highly restricted, since compounds must cross a series of structural
and metabolic barriers to reach their final destination, often a cellular compartment such …
and metabolic barriers to reach their final destination, often a cellular compartment such …
Critical review of preclinical approaches to investigate cytochrome P450–mediated therapeutic protein drug-drug interactions and recommendations for best practices …
R Evers, S Dallas, LJ Dickmann, OA Fahmi… - Drug Metabolism and …, 2013 - ASPET
Drug-drug interactions (DDIs) between therapeutic proteins (TPs) and small-molecule drugs
have recently drawn the attention of regulatory agencies, the pharmaceutical industry, and …
have recently drawn the attention of regulatory agencies, the pharmaceutical industry, and …
Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
X Wu, PS Chen, S Dallas, B Wilson… - International Journal …, 2008 - academic.oup.com
Parkinson's disease (PD) is characterized by the selective and progressive loss of dopaminergic
(DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable …
(DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable …
Microglial PHOX and Mac‐1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha‐synuclein
W Zhang, S Dallas, D Zhang, JP Guo, H Pang… - Glia, 2007 - Wiley Online Library
α‐Synuclein, a gene whose mutations, duplication, and triplication has been linked to
autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the …
autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the …
Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity
S Levesque, B Wilson, V Gregoria, LB Thorpe, S Dallas… - Brain, 2010 - academic.oup.com
Microglia, the innate immune cells in the brain, can become chronically activated in response
to dopaminergic neuron death, fuelling a self-renewing cycle of microglial activation …
to dopaminergic neuron death, fuelling a self-renewing cycle of microglial activation …
MAC1 mediates LPS‐induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity
…, LI Qian, S Yang, T Wang, W Zhang, X Wu, S Dallas… - Glia, 2007 - Wiley Online Library
Microglia‐derived superoxide is critical for the inflammation‐induced selective loss of
dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly …
dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly …
The peroxidase activity of mitochondrial superoxide dismutase
Manganese superoxide dismutase (MnSOD) is an integral mitochondrial protein known as a
first-line antioxidant defense against superoxide radical anions produced as by-products of …
first-line antioxidant defense against superoxide radical anions produced as by-products of …
Galactosylated cellulosic sponge for multi-well drug safety testing
…, JM Robens, M McMillian, J Silva, S Dallas… - Biomaterials, 2011 - Elsevier
Hepatocyte spheroids can maintain mature differentiated functions, but collide to form bulkier
structures when in extended culture. When the spheroid diameter exceeds 200 μm, cells in …
structures when in extended culture. When the spheroid diameter exceeds 200 μm, cells in …
Multidrug resistance protein (MRP) 4-and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl) adenine by microglia
S Dallas, L Schlichter, R Bendayan - Journal of Pharmacology and …, 2004 - ASPET
The pathogenesis of human immunodeficiency virus (HIV)-associated dementia has been
linked to microglial responses after infection. We have recently confirmed expression of …
linked to microglial responses after infection. We have recently confirmed expression of …