Female rats display a more robust behavioral response to acute cocaine administration
than do male rats. However, a clear understanding of the biological mechanisms underlying …

In vitro metabolism of methadone was investigated in cytochrome P450 (CYP) supersomes
and phenotyped human liver microsomes (HLMs) to reconcile past findings on CYP …

Although there is growing evidence that neurotoxic molecules produced by HIV-1-infected
mononuclear phagocytes damage neurons, the precise mechanisms of neuronal attack …

Soybean consumption may be protective for breast cancer, possibly due in part to the presence
of the isoflavones daidzein and genistein, which are weakly estrogenic. The metabolism …

Oxidative modification of LDL may be important in the initiation and/or progression of
atherosclerosis, but the precise mechanisms through which low density lipoprotein (LDL) is …

Cocaine withdrawal symptoms are thought to play a role in relapse; studies characterizing
the symptomatology have yielded mixed findings. This study sought to examine the …

Contemporary analytical systems based on mass spectrometry include as components a gas
chromatograph, a mass spectrometer, and a computer. The form of operation is usually in …

Quetiapine is an atypical antipsychotic agent for the treatment of schizophrenia. After an oral
dose it is absorbed rapidly and extensively metabolized in the liver, resulting in low plasma …

The combination of microdialysis and fast-atom bombardment mass spectrometry has been
used to follow the pharmacokinetics of penicillin G directly in the blood-stream of a live rat. …

GC‐mass spectrometry was used to measure extremely low levels of fentanyl in dog plasma.
Deuterated fentanyl was synthesized for use as an internal standard. Fentanyl was …