Obesity and its metabolic consequences are a major public health concern worldwide.
Obesity is associated with overactivity of the endocannabinoid system, which is involved in the …

Background It is becoming clear that various cytokines are associated with the spread of
cancer cells. The purpose of this study was to compare interleukin (IL)-6 levels in patients with …

Multidrug resistance caused by the overexpression of ABC drug transporters is a major
obstacle in clinical cancer chemotherapy. For several years, it appeared that direct inhibition of …

Ndc80 has been shown to play an important role in stable microtubule-kinetochore attachment,
chromosome alignment, and spindle checkpoint activation in mitosis. It is composed of …

The drug efflux function of P-glycoprotein (P-gp) encoded by MDR1 can be influenced by
genetic polymorphisms, including two synonymous changes in the coding region of MDR1. …

Background and Aims Since 2009, the Japanese Society for Cancer of the Colon and Rectum
guidelines have recommended that tumor budding and submucosal invasion depth, in …

One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance
(MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an …

BACKGROUND: Alternative splicing is a molecular mechanism by which different combinations
of exons can be alternatively spliced to produce different mRNA isoforms. Recently, …

Runt‐related transcription factor 2 (RUNX2) belongs to the RUNX family of heterodimeric
transcription factors, and is mainly associated with osteogenesis. Previous in vitro studies …

We determined the gene expression profiles for 48 ATP binding cassette ( ABC ) transporters
in matched colon cancer and normal colon tissues in order to provide insight into the …