User profiles for Shinya Shibutani

Shinya Shibutani

Stony Brook University
Verified email at stonybrook.edu
Cited by 10686

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

S Shibutani, M Takeshita, AP Grollman - Nature, 1991 - nature.com
OXIDATIVE damage to DNA, reflected in the formation of 8-oxo- 7-hydrodeoxyguanosine (8-oxodG)
1,2 , may be important in mutagenesis, carcinogenesis and the ageing process 3,4 . …

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

AP Grollman, S Shibutani, M Moriya… - Proceedings of the …, 2007 - National Acad Sciences
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women
living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by …

Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells

A Mizutani, T Okada, S Shibutani, E Sonoda… - Cancer Research, 2004 - AACR
Tamoxifen (TAM) possesses antiestrogen activity and is widely used for the treatment or
prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver, …

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

J Tchou, V Bodepudi, S Shibutani… - Journal of Biological …, 1994 - ASBMB
The 8-oxoguanine-DNA glycosylase of Escherichia coli, also known as formamidopyrimidine-DNA
glycosylase (Fpg protein), has N-glycosylase and AP-lyase activities. This enzyme …

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG (syn) …

M Kouchakdjian, V Bodepudi, S Shibutani… - Biochemistry, 1991 - ACS Publications
Revised Manuscript Received October 1, 1990 abstract: Proton NMR studies are reported
on the complementary d (Cl-C2-A3-C4-T5-A6-oxo-G7-T8-C9-A10-C1 l-C12)* d (G13-G14-T15-…

Selective toxicity of aristolochic acids I and II

S Shibutani, H Dong, N Suzuki, S Ueda, F Miller… - Drug Metabolism and …, 2007 - ASPET
Ingestion of herbal remedies containing aristolochic acids (AAs) is associated with the
development of a syndrome, designated aristolochic acid nephropathy (AAN), which is …

[HTML][HTML] Translesional synthesis on DNA templates containing a single abasic site: A mechanistic study of the “A rule”

S Shibutani, M Takeshita, AP Grollman - Journal of Biological Chemistry, 1997 - ASBMB
Site-specifically modified oligodeoxynucleotides containing a single natural abasic site or a
chemically synthesized (tetrahydrofuran or deoxyribitol) model abasic site were used as …

Increased DNA damage in ALDH2-deficient alcoholics

…, H Yabushita, RA Kanaly, S Shibutani… - Chemical research in …, 2006 - ACS Publications
Drinking alcohol is a risk factor for cancers of the oral cavity, pharynx, larynx, and esophagus.
Although many studies suggest that acetaldehyde, a major metabolite of orally ingested …

Translesion Synthesis by Human DNA Polymerase κ on a DNA Template Containing a Single Stereoisomer of dG-(+)- or dG-(−)-anti-N2-BPDE (7,8-Dihydroxy-anti-9,10-epoxy …

…, AP Grollman, H Ohmori, S Shibutani - Biochemistry, 2002 - ACS Publications
Several recently discovered human DNA polymerases are associated with translesion
synthesis past DNA adducts. These include human DNA polymerase κ (pol κ), a homologue of …

Comparison of the mutagenic properties of 8-oxo-7, 8-dihydro-2′-deoxyadenosine and 8-oxo-7, 8-dihydro-2′-deoxyguanosine DNA lesions in mammalian cells

X Tan, AP Grollman, S Shibutani - Carcinogenesis, 1999 - academic.oup.com
The comparative mutagenicity of 8-oxo-7,8-dihydro-2′-deoxyadenosine (8-oxodA) and 8-oxo-7,8-dihydro-2′-deoxyguanosine
(8-oxodG) was explored using simian kidney (COS-7) …