Time-course mass spectrometry imaging for depicting drug incorporation into hair

T Kamata, N Shima, K Sasaki, S Matsuta… - Analytical …, 2015 - ACS Publications
In order to investigate the incorporation of drugs into hair, matrix-assisted laser desorption/ionization–time-of-flight
tandem mass spectrometry (MS/MS) imaging was performed on the …

Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites

N Shima, M Katagi, H Kamata, S Matsuta, K Sasaki… - Forensic …, 2014 - Springer
Urinary metabolites of α-pyrrolidinovalerophenone (α-PVP) in humans were investigated by
analyzing urine specimens obtained from abusers. Unambiguous identification and …

Development of a simple one-pot extraction method for various drugs and metabolites of forensic interest in blood by modifying the QuEChERS method

S Matsuta, K Nakanishi, A Miki, K Zaitsu… - Forensic Science …, 2013 - Elsevier
A rapid and convenient extraction method has been developed for the determination of
various drugs and metabolites of forensic interest in blood by modifying the dispersive solid-…

Incorporation of zolpidem into hair and its distribution after a single administration

N Shima, K Sasaki, T Kamata, S Matsuta… - Drug Metabolism and …, 2017 - ASPET
To obtain fundamental information on the drug incorporation into hair, time-course changes
in drug distribution along single-strand hair were observed after a single oral administration …

Metabolism of the designer drug α-pyrrolidinobutiophenone (α-PBP) in humans: identification and quantification of the phase I metabolites in urine

S Matsuta, N Shima, H Kamata, H Kakehashi… - Forensic Science …, 2015 - Elsevier
Urinary phase I metabolites of α-pyrrolidinobutiophenone (α-PBP) in humans were investigated
by analyzing urine specimens obtained from drug abusers. Unequivocal identification …

Positional isomer differentiation of synthetic cannabinoid JWH‐081 by GC‐MS/MS

…, K Hisatsune, T Moriyasu, S Matsuta… - Journal of Mass …, 2015 - Wiley Online Library
Like many new designer drugs of abuse, synthetic cannabinoids (SC) have structural or
positional isomers which may or may not all be regulated under law. Differences in acute toxicity …

Single-hair analysis of zolpidem on the supposition of its single administration in drug-facilitated crimes

N Shima, K Sasaki, T Kamata, S Matsuta, M Katagi… - Forensic …, 2015 - Springer
Little information is available on the amounts of hypnotics incorporated into hair after a
single administration and about effective analytical procedures to document cases like drug-…

Effects of lipophilicity and functional groups of synthetic cannabinoids on their blood concentrations and urinary excretion

…, A Nitta, R Asai, M Wada, S Nakano, S Matsuta… - Forensic science …, 2020 - Elsevier
The influence of lipophilicity and functional groups of synthetic cannabinoids (SCs) on their
blood concentrations and urinary excretion has been studied by analyzing blood and urine …

Urinary excretion and metabolism of the α-pyrrolidinophenone designer drug 1-phenyl-2-(pyrrolidin-1-yl) octan-1-one (PV9) in humans

N Shima, H Kakehashi, S Matsuta, H Kamata… - Forensic …, 2015 - Springer
Phenyl-2-(pyrrolidin-1-yl)octan-1-one (PV9) and 16 metabolites, including diastereomers and
conjugates, were identified or tentatively detected in human urine by gas chromatography–…

Incorporation of zolpidem and methoxyphenamine into white hair strands after single administrations: Influence of hair pigmentation on drug incorporation

N Shima, A Nitta, T Kamata, K Sasaki, S Matsuta… - Forensic science …, 2019 - Elsevier
In order to investigate the influence of pigmentation on the incorporation of drugs into hair,
time-course changes in drug distribution along non-pigmented (white) hairs as well as …