The structures of the ligand-binding domains (LBD) of the wild-type androgen receptor (AR)
and the T877A mutant corresponding to that in LNCaP cells, both bound to …

An open question in protein homology modeling is, how well do current modeling packages
satisfy the dual criteria of quality of results and practical ease of use? To address this …

We describe the proceedings and conclusions from the "Workshop on Applications of
Protein Models in Biomedical Research" (the Workshop) that was held at the University of …

A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR)
modulator (BMS-564929) has been identified, and this compound has been advanced to …

Adnectins are targeted biologics derived from the tenth type III domain of human fibronectin (
10 Fn3), a member of the immunoglobulin superfamily. Target-specific binders are selected …

Protein aggregation is a phenomenon that has attracted considerable attention within the
pharmaceutical industry from both a developability standpoint (to ensure stability of protein …

Epitope mapping the specific residues of an antibody/antigen interaction can be used to
support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus…

Chemical modifications can potentially change monoclonal antibody’s (mAb) local or global
conformation and therefore impact their efficacy as therapeutic drugs. Modifications in the …

In addition to high-throughput screening (HTS), the main lead discovery technology employed
by most pharmaceutical companies today is virtual screening (VS). Although the two …

… In the present study we present further details from our initial study (Krystek et al., 1991) and
evidence that indicates that ET-1displays conformational averaging in some portions of the …