eIF2B activator prevents neurological defects caused by a chronic integrated stress response

…, M Roy, A Ireland, JM Frost, L Shi, S Riedmaier… - Elife, 2019 - elifesciences.org
10.7554/eLife.42940.001 The integrated stress response (ISR) attenuates the rate of protein
synthesis while inducing expression of stress proteins in cells. Various insults activate …

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes

DM Feidt, K Klein, U Hofmann, S Riedmaier… - Drug Metabolism and …, 2010 - ASPET
Human hepatocytes in primary culture are a very useful model to directly assess induction of
gene expression by xenobiotics. We developed a cytochrome P450 (P450) activity cocktail …

[HTML][HTML] Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes …

…, HS Wong, PA Dighe, B McKibben, S Riedmaier… - Free Radical Biology …, 2023 - Elsevier
We developed S1QEL1.719, a novel bioavailable S1QEL (suppressor of site I Q electron
leak). S1QEL1.719 prevented superoxide/hydrogen peroxide production at site I Q of …

Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry

G Redlich, UM Zanger, S Riedmaier… - Journal of proteome …, 2008 - ACS Publications
In mammals, Cytochrome P450 (CYP) enzymes are bound to membranes of the endoplasmic
reticulum and mitochondria, where they are responsible for the oxidative metabolism of …

[HTML][HTML] Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

S Riedmaier, K Klein, S Winter, U Hofmann… - Frontiers in …, 2011 - frontiersin.org
Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated
with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence …

[HTML][HTML] Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

…, T Esbenshade, B McKibben, S Riedmaier… - Free Radical Biology …, 2021 - Elsevier
Superoxide produced by mitochondria has been implicated in numerous physiologies and
pathologies. Eleven different mitochondrial sites that can produce superoxide and/or …

Effect of gemfibrozil, rifampicin, or probenecid on the pharmacokinetics of the SGLT2 inhibitor empagliflozin in healthy volunteers

…, R Sennewald, K Schöne, N Hummel, S Riedmaier… - Clinical …, 2014 - Elsevier
… Macha, Koenen, Sennewald, and Riedmaier were involved in the acquisition of data; and
Drs. Macha, Koenen, Sennewald, Schöne, Hummel, Riedmaier, Woerle, Salsali, and Broedl …

[HTML][HTML] A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

J Bucher, S Riedmaier, A Schnabel, K Marcus… - BMC systems …, 2011 - Springer
Background The individual character of pharmacokinetics is of great importance in the risk
assessment of new drug leads in pharmacological research. Amongst others, it is severely …

[PDF][PDF] Profiling induction of cytochrome P450 enzyme activity by statins using a new LC-MS/MS cocktail assay in human hepatocytes

DM Feidt, K Klein, U Hofmann, S Riedmaier… - Drug Metabolism and …, 2010 - Citeseer
Human hepatocytes in primary culture are a very useful model to directly assess induction of
gene expression by xenobiotics. We developed a cytochrome P450 (CYP) activity cocktail …

Pharmacogenetic Determinants of Atorvastatin Metabolism and Response

S Riedmaier - 2011 - ub01.uni-tuebingen.de
High levels of LDL-cholesterol are associated with an increased risk for atherosclerosis and
cardiovascular events. Atorvastatin is a very effective HMG-CoA reductase inhibitor …