Intestinal lymphatic transport for drug delivery
JA Yáñez, SWJ Wang, IW Knemeyer, MA Wirth… - Advanced drug delivery …, 2011 - Elsevier
Intestinal lymphatic transport has been shown to be an absorptive pathway following oral
administration of lipids and an increasing number of lipophilic drugs, which once absorbed, …
administration of lipids and an increasing number of lipophilic drugs, which once absorbed, …
Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides
The purposes of this study were to investigate how efflux transporters and UDP-glucuronosyltransferases
(UGT) affect the disposition of naringenin. A rat intestinal perfusion model with …
(UGT) affect the disposition of naringenin. A rat intestinal perfusion model with …
Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine
W Zhu, H Xu, SWJ Wang, M Hu - The AAPS journal, 2010 - Springer
The low bioavailability of genistein has impeded its development into a therapeutic agent.
Our earlier studies indicate that glucuronidation is one of the major barriers to genistein oral …
Our earlier studies indicate that glucuronidation is one of the major barriers to genistein oral …
Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties
The purpose of this study is to determine the importance of coupling of efflux transporters
and metabolic enzymes in the intestinal disposition of six isoflavones (genistein, daidzein, …
and metabolic enzymes in the intestinal disposition of six isoflavones (genistein, daidzein, …
Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities
SWJ Wang, KH Kulkarni, L Tang, JR Wang, T Yin… - … of Pharmacology and …, 2009 - ASPET
Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases
(UGTs). This study aims to further understand the functions of UGT in …
(UGTs). This study aims to further understand the functions of UGT in …
Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein
SWJ Wang, Y Chen, T Joseph, M Hu - The Journal of Alternative …, 2008 - liebertpub.com
Background: Marketed red clover (Trifoleum pratense) products use a wide variety of labels,
and the isoflavone content from the label is ambiguous. Materials and methods: In the …
and the isoflavone content from the label is ambiguous. Materials and methods: In the …
Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms
…, SWJ Wang, X Liu, KH Kulkarni, J Wang… - Molecular …, 2007 - ACS Publications
We characterized the in vitro glucuronidation of prunetin, a prodrug of genistein that is a
highly active cancer prevention agent. Metabolism studies were conducted using expressed …
highly active cancer prevention agent. Metabolism studies were conducted using expressed …
Stereospecific high-performance liquid chromatographic analysis of ibuprofen in rat serum
XW Teng, SWJ Wang, NM Davies - Journal of Chromatography B, 2003 - Elsevier
A simple, rapid and sensitive high-performance liquid chromatographic method was
developed for determination of ibuprofen, (±)-(R, S)-2-(4-isobutylphenyl)-propionic acid, …
developed for determination of ibuprofen, (±)-(R, S)-2-(4-isobutylphenyl)-propionic acid, …
Stereospecific high-performance liquid chromatographic analysis of flurbiprofen: application to pharmacokinetic studies
XW Teng, SWJ Wang, NM Davies - Journal of pharmaceutical and …, 2003 - Elsevier
A method of analysis of flurbiprofen (+/− 2-(2-fluoro-4-biphenyl)-propionic acid) in biological
fluids is necessary to study the kinetics of in vitro and in vivo metabolism and tissue …
fluids is necessary to study the kinetics of in vitro and in vivo metabolism and tissue …
Effects of restraint stress and serotonin on macronutrient selection: a rat model of stress-induced anorexia
SWJ Wang - Eating and Weight Disorders-Studies on Anorexia …, 2002 - Springer
The present study investigated the effects of brief (20 min), acute (2 hr) and chronic restraint
stress (2 hr/day for five days) at the time of dark onset on macronutrient selection in female …
stress (2 hr/day for five days) at the time of dark onset on macronutrient selection in female …