Intestinal lymphatic transport for drug delivery

JA Yáñez, SWJ Wang, IW Knemeyer, MA Wirth… - Advanced drug delivery …, 2011 - Elsevier
Intestinal lymphatic transport has been shown to be an absorptive pathway following oral
administration of lipids and an increasing number of lipophilic drugs, which once absorbed, …

Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides

…, KH Kulkarni, R Singh, Z Yang, SWJ Wang… - Molecular …, 2009 - ACS Publications
The purposes of this study were to investigate how efflux transporters and UDP-glucuronosyltransferases
(UGT) affect the disposition of naringenin. A rat intestinal perfusion model with …

Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine

W Zhu, H Xu, SWJ Wang, M Hu - The AAPS journal, 2010 - Springer
The low bioavailability of genistein has impeded its development into a therapeutic agent.
Our earlier studies indicate that glucuronidation is one of the major barriers to genistein oral …

Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties

SWJ Wang, J Chen, X Jia, VH Tam, M Hu - Drug metabolism and disposition, 2006 - ASPET
The purpose of this study is to determine the importance of coupling of efflux transporters
and metabolic enzymes in the intestinal disposition of six isoflavones (genistein, daidzein, …

Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities

SWJ Wang, KH Kulkarni, L Tang, JR Wang, T Yin… - … of Pharmacology and …, 2009 - ASPET
Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases
(UGTs). This study aims to further understand the functions of UGT in …

Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein

SWJ Wang, Y Chen, T Joseph, M Hu - The Journal of Alternative …, 2008 - liebertpub.com
Background: Marketed red clover (Trifoleum pratense) products use a wide variety of labels,
and the isoflavone content from the label is ambiguous. Materials and methods: In the …

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms

…, SWJ Wang, X Liu, KH Kulkarni, J Wang… - Molecular …, 2007 - ACS Publications
We characterized the in vitro glucuronidation of prunetin, a prodrug of genistein that is a
highly active cancer prevention agent. Metabolism studies were conducted using expressed …

Stereospecific high-performance liquid chromatographic analysis of ibuprofen in rat serum

XW Teng, SWJ Wang, NM Davies - Journal of Chromatography B, 2003 - Elsevier
A simple, rapid and sensitive high-performance liquid chromatographic method was
developed for determination of ibuprofen, (±)-(R, S)-2-(4-isobutylphenyl)-propionic acid, …

Stereospecific high-performance liquid chromatographic analysis of flurbiprofen: application to pharmacokinetic studies

XW Teng, SWJ Wang, NM Davies - Journal of pharmaceutical and …, 2003 - Elsevier
A method of analysis of flurbiprofen (+/− 2-(2-fluoro-4-biphenyl)-propionic acid) in biological
fluids is necessary to study the kinetics of in vitro and in vivo metabolism and tissue …

Effects of restraint stress and serotonin on macronutrient selection: a rat model of stress-induced anorexia

SWJ Wang - Eating and Weight Disorders-Studies on Anorexia …, 2002 - Springer
The present study investigated the effects of brief (20 min), acute (2 hr) and chronic restraint
stress (2 hr/day for five days) at the time of dark onset on macronutrient selection in female …